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临床试验/NCT01887977
NCT01887977Unknown不适用

Computational Modeling for Prediction of Acoustic Changes in Vowel Production

Turku University Hospital2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2012年3月最近更新:
适应症

试验速览

阶段
不适用
入组人数
20
试验地点
2
主要终点
Acoustic changes in vowel production of hte patients duoe to orthognathic surgery

研究概览

简要总结

A computational model of human sound production based on high quality anatomic measurements and physical laws of sound propagation cannot be accomplished without a comprehensive data set including both 3D-images of the speaker's anatomy and the simultaneous recording of speech. Since the computational model has separate models for the vocal folds and the vocal tract, patients undergoing an orthognathic surgery is an optimal test object for the model development. Vocal folds remain unchanged while substantial changes take place in the vocal tract. Moreover, since the aim of the research is to predict acoustic changes in speech due to operations in head neck area, the orthognathic patient group is par excellence an example of such a prediction problem. If the model can be shown to give valuable information pre-operationally, many other patient groups could benefit from the results.

详细描述

Orthognathic surgery deals with the correction of abnormalities of the facial tissues. The underlying cause for abnormality may be present at birth or acquired during the life as the result of distorted growth or trauma. Orthodontic treatment alone is not adequate in many cases due to severity of the deformities. In a typical operation, the position of either one jaw (mandible or maxilla) or both jaws is surgically changed in relation to the skull base. The movement of the jaw position varies usually between 5-15 mm either to anterior or posterior direction. Such a considerable movement has a very profound effect on the shape and volume of vocal tract resulting detectable changes in acoustics. Although the surgery involves mandibular and maxillary bone, changes occur also in the position and shape of respective soft tissues and hyoid bone, as well. For this project, 20 adult patients (10 women and 10 men) undergoing orthognathic surgery will be enrolled. Exclusion criteria include diseases and conditions in which MRI examination is contraindicated (.e.g. pace maker), severe speech or hearing impairment, and other situations where the patient has difficulties with completing the tasks defined in the research protocol. Furthermore, patients to whom segmental surgery of the jaws will be performed in connection of orthognathic surgery are excluded. A specific pre-selection criterion for patients is the presence of numerous dental amalgam fillings that may cause artifacts in MR images.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
盲法
None

入排标准

年龄范围
18 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy patients undergoing orthognathic surgery

排除标准

  • Patients with conditions in which MRI examination is contraindicated (e.g. pace maker)
  • Patients who require several operations or segmented jaw surgery
  • Patients with cognitive impairment
  • Patients with numerous dental amalgam fillings that may cause artifacts in MR images

结局指标

主要结局

Acoustic changes in vowel production of hte patients duoe to orthognathic surgery

时间窗: 6 and 30 weeks postoperatively

a measurement of sound formants

次要结局

  • Anatomical changes in vocal tract due to orthognathic surgery(6 and 30 weeks postoperatively)

研究者

申办方类型
Other Gov
责任方
Sponsor

研究点 (2)

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