The Effect of Exercise and/or Diet Body Composition, Cardiorespiratory Fitness and Blood Parameters Related to Improved Health in Overweight Females.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 57
- 试验地点
- 2
- 主要终点
- Area under curve (AUC) glucose
研究概览
简要总结
The study evaluates the effect of exercise and/or diet during on body weight, body composition and health related blood parameters. Participants are overweight sedentary females, allocated to four different groups: Normal diet, Low-carb-high-fat diet, Normal diet + exercise, Low-carb-high-fat diet + exercise.
详细描述
Diet and exercise can both be efficient tools to reduce bodyweight, get healthier body composition and improve many different health related blood parameters such as cholesterol and glucose tolerance.
Exercise has superior effect on skeletal muscle in the context of glucose tolerance, but adherence to exercise program can be a huge challenge for overweight individuals. While exercise has profound effect on metabolic health, diet has been superior when it comes to weight reduction. Previous studies have shown that 5-7% weight loss can improve glucose tolerance, measured as reduced fasting glucose and reduced 2-hour post prandial glucose.
We wish to see if the combination exercise and diet is superior to diet only when it comes to over all health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 33 Years 至 47 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Sedentary
- •Premenopausal
- •Caucasian
- •BMI 26.9 - 36.1
- •Living close to, or in Oslo.
排除标准
- •Pregnancy
- •Breast-feeding
- •Smoking or tobacco use
- •Previous medical history of cardio-vascular disease (CVD)
- •Previous medical history of diabetes
- •Previous medical history of endocrine disorder
- •Previous medical history of kidney disease
- •Use of lipid lowering medication
- •Use of diabetes medication
结局指标
主要结局
Area under curve (AUC) glucose
时间窗: Change from baseline AUC glucose at 10 weeks
AUC glucose measured during an OGTT
次要结局
- Body composition(Change from baseline values at 10 weeks)
- Cardiorespiratory fitness(Change from baseline values at 10 weeks)
- Lipid profile(Change from Baseline lipids at 10 weeks)