NCT03344393Unknown不适用
Effect of Intraoperative IV Ketamine on Postoperative Morphine Consumption During Intestinal Surgery and Its Effect on Salivary Cortisol and Alpha Amylase Levels
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- morphine consumption
研究概览
简要总结
.The aim of this study is to identify the analgesic effect of intraoperative ketamine intravenous infusion on patients undergoing intestinal surgery and its effect on salivary cortisol and alpha amylase levels as indicator of its effect.
详细描述
I- Group K (ketamine): 30 patients will receive intraoperative intravenous ketamine infusion.
II- Group C (control): 30 patients will receive intraoperative intravenous normal saline infusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Patient's status ASA status-I and II.
- •Patients age above 18 years old.
- •Patients scheduled for intestinal surgery.
排除标准
- •Patient refusal.
- •Patients with known allergy to ketamine or morphine.
- •Patients with significant hepatic dysfunction.
- •Patients with severe renal disease.
- •Significant Heart disease.
- •Patients with chronic pain.
- •Regular use analgesics, antidepressants or opioids in last 2 months.
- •Any known convulsive disorder.
- •Morbid obesity (BMI>35).
- •Patients with autoimmune disease
- •Patients on corticosteroid therapy
- •Pregnancy.
- •Breast feeding.
- •Woman under hormonal treatment.
- •Oral disease.
研究组 & 干预措施
ketamine hydrochloride
Active Comparator
intravenous ketamine infusion in the intraoperative period
干预措施: Ketamine Hydrochloride (Drug)
normal saline
Active Comparator
intravenous normal saline infusion in the intraoperative period
干预措施: Normal saline (Drug)
结局指标
主要结局
morphine consumption
时间窗: 2 days postoperative
IV PCA
次要结局
- cortisol level(2 days postoperative)
- alpha amylase level(2 days postoperative)
研究者
Mohamed galal aly
Assistant Professor
Assiut University
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