Impact of Breast Milk on the Infectivity and Transmission of Different Viruses "BREASTMILKVIR"
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Study the influence of breast milk and its composition on viral infectivity and oral transmission of HTLV-1 and arboviruses such as Zika virus, yellow fever virus, dengue virus, and tick-borne encephalitis virus.
研究概览
简要总结
Exclusive breastfeeding during the first six months of life and continued breastfeeding for at least 24 months constitute the optimal feeding method for infants and young children.
However, breast milk and breastfeeding can be significant pathways for the transmission of certain viruses.
The objective of this study is to examine the influence of human breast milk and its composition on viral infectivity and viral transmission of the HTLV-1 virus and arboviruses such as Zika virus, yellow fever, dengue, and tick-borne encephalitis.
详细描述
Exclusive breastfeeding during the first six months of life and continued breastfeeding for at least 24 months constitute the optimal feeding method for infants and young children.
However, breast milk and breastfeeding can be significant pathways for the transmission of at least three human viruses: HTLV-1, HIV, and human cytomegalovirus (CMV).
To address the following main objective: to study the influence of human breast milk and its composition on viral infectivity and viral transmission of the HTLV-1 virus and arboviruses such as Zika virus, yellow fever, dengue, and tick-borne encephalitis.The study plans to collect milk samples from lactating women who are registered with the Lactarium of Île-de-France to donate their breast milk.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age > 18 years
- •Female gender
- •Lactarium Ile-de-France donors
- •Subjects covered by a Social Security scheme, excluding State Medical Aid
- •No inclusion criteria:
- •- Women opposing participation in the study
排除标准
- •- Positive HIV, HBV, HCV and HTLV serologies (Lactarium exclusion criteria)
结局指标
主要结局
Study the influence of breast milk and its composition on viral infectivity and oral transmission of HTLV-1 and arboviruses such as Zika virus, yellow fever virus, dengue virus, and tick-borne encephalitis virus.
时间窗: 36 months
Various viruses will be incubated with milk samples. The influence of milk on the different viruses will be studied. The capacity of these viruses incubated with milk to infect the target cells (immune or epithelial cells, depending on the virus) will be measured (measurement of the number of infected cells).
次要结局
- Determine the antiviral or proviral mechanisms of certain biological factors in breast milk.(36 months)
- Determine the role of breast milk in the mechanisms by which the relevant viruses cross an epithelium.(36 months)
- Determine the influence of a few hours of incubation at 4°C (refrigeration) on the previously mentioned mechanisms.(36 months)