NCT00460044已完成不适用
Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants
Amsterdam UMC, location VUmc0 个研究点目标入组 35 人开始时间: 2002年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 35
研究概览
简要总结
The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.
详细描述
Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.
研究设计
- 研究类型
- Observational
- 观察模型
- Defined Population
- 时间视角
- Other
入排标准
- 年龄范围
- — 至 32 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Gestational age < 32 weeks
- •Birth weight < 1500 gram
- •Written informed consent of parents
排除标准
- •Congenital abnormalities
- •Chromosomal abnormalities
研究者
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