Neocortical Microarchitecture of Executive Function Using Large-scale Intracranial Electrophysiology
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Measure the neural population representations of task parameters along, and within, the cortical layers.
研究概览
简要总结
This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.
详细描述
This project aims to use Neuropixels probes to record hundreds of neurons during awake human intracranial surgeries. Using this probe, we will take advantage of access to a key area in the network involved in executive function, the middle frontal gyrus of the dorsal lateral Pre Frontal Cortex (approximately the mid portion of dlPFC, part of Brodmann area 9/46), to test emerging concepts that cognitive flexibility so crucial to human EF is encoded in neural population geometry and layer-specific interactions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Device Feasibility
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Parkinson's disease and refractory to medications requiring deep brain stimulation
- •Able to provide informed consent
- •Normal neuropsychiatric evaluation that includes tests of executive function demonstrating no greater than mild impairments, within expectation for Parkinson's disease.
- •Medically able to undergo deep brain stimulation surgery as evaluated by study neurosurgeon.
- •Surgical plan includes an entry point that can safely be placed in the dorsal lateral PFC.
- •Able to tolerate awake deep brain stimulation surgery with a plan for the case to be done awake.
- •Able to tolerate 25 additional minutes of awake surgery.
- •Able to participate and comply with tasks adequately, including instructions provided in English.
排除标准
- •Moderate, or severe cognitive impairment as determined by a licensed neuropsychologist during routine neuropsychological evaluation.
- •Inability to tolerate awake surgery as determined by the treating neurologist and study neurosurgeon.
- •Inability to safely access the dorsal lateral prefrontal cortex for an entry location.
- •Moderate or severe cognitive impairment or executive function deficits as determined by neuropsychological testing.
- •Evidence of a clinically significant abnormality on preoperative imaging.
结局指标
主要结局
Measure the neural population representations of task parameters along, and within, the cortical layers.
时间窗: 20 minutes
次要结局
- Measure the neural population dimensionality in response to changing task parameters(20 minutes)