Cognitive Disorders and Brain Pulse
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- maximum amplitude of brain movements
研究概览
简要总结
Following an initial consultation with a memory, resources and research centre (MRRC) doctor, a day hospital may be prescribed to carry out an assessment of cognitive disorders. Patients are then usually followed up in consultation at least once a year, in the framework of a new day hospital and/or consultations with a MRRC doctor.
详细描述
Patients will be included at the time of the day hospital assessment. All patients received in the day hospital of the MRRC of Tours will be offered the TPI examination. The patients included will be followed up for a period of 5 years and the TPI examination will be repeated according to the same modalities, as part of their follow-up at the MRRC and/or in the context of a new day hospital if necessary.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient benefiting from a day hospital at the MRRC of the CHU of Tours for assessment of cognitive functions
排除标准
- •Refusal of TPI ultrasound examination
- •Patients who opposed to data processing
- •Patients under judicial protection
研究组 & 干预措施
assessment of cognitive functions
Assessment of cognitive disorders with an ultrasound examination performed in routine care during a day hospital.
干预措施: Ultrasound examination (Other)
结局指标
主要结局
maximum amplitude of brain movements
时间窗: one a year from inclusion visit to 5 years
Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
powers in frequency analysis
时间窗: one a year from inclusion visit to 5 years
Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
mean of brain movements
时间窗: one a year from inclusion visit to 5 years
Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
standard deviation of brain movements
时间窗: one a year from inclusion visit to 5 years
Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
次要结局
- cohort study on brain pulsatility with neuropsychological measures(one a year from inclusion visit to 5 years)
- Carbohydrate metabolism(one a year from inclusion visit to 5 years)
- Hippocampal volume(one a year from inclusion visit to 5 years)
- Spinal fluid biomarkers(one a year from inclusion visit to 5 years)
- leucoaraiosis load(one a year from inclusion visit to 5 years)
- Brain pulse(one a year from inclusion visit to 5 years)