Exercise in Patients With Metabolic Syndrome and Weight Regain - Echocardiography Substudy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 主要终点
- Mean Resting E/E'
研究概览
简要总结
We plan to test the hypothesis that patients with metabolic syndrome will have impaired left ventricular diastolic parameters. These parameters will be measured before and after a stress test at the end of a 3 month period of exercise training and a 10% weight loss.
详细描述
Patients must have 2 of the 5 criteria for metabolic syndrome and be able to exercise in a monitored setting for 45 min 5 times a week.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •2 of 5 criteria for metabolic syndrome
- •Ability to exercise for 45 min 5 days a week
排除标准
- •No diabetes
- •Established coronary disease
结局指标
主要结局
Mean Resting E/E'
时间窗: 12 weeks
E/E' is an echocardiographic parameter where E = early mitral inflow velocity and E' = early diastolic mitral annular motion. Measured in all participants prior to treadmill stress test.
Post-exercise E/E'
时间窗: 12 weeks
E/E' is an echocardiographic parameter where E = early mitral inflow velocity and E' = early diastolic mitral annular motion. Measured in all participants immediately following treadmill stress test.
次要结局
- Change in Maximal Oxygen Uptake (VO2 Max)(12 weeks)
- Mean Resting Maximal Oxygen Uptake (VO2 Max)(12 weeks)