Comparative and Interventional Study on Healing Outcomes with and Without Platelet Rich Plasma (PRP) in Third Molar Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- This study will help us determine the effectiveness of PRP in healing outcome of third molar surgery to reduced swelling and pain
研究概览
简要总结
The overall aim is to evaluate the therapeutic effect of Platelet-Rich Plasma (PRP) in third molar extraction sockets, focusing on reducing pain, improving wound healing, and enhancing patient comfort during the post-operative period. Surgical removal of impacted third molars frequently results in post-surgical issues such as pain, swelling, and trismus (limited mouth opening).
PRP is an autologous concentrate of platelets suspended in plasma, rich in growth factors (like Platelet derived growth factor, Transforming growth factor-b, and Vascular endothelial growth factor). These factors promote angiogenesis, tissue regeneration, soft tissue repair, and accelerate recovery.
The study objectives include comparing post-operative pain (using the Visual Analogue Scale), wound healing (using the Healing Index), mouth opening, and swelling between groups with and without PRP on the 3rd and 7th post-operative days. The required sample size is 70 participants (35 per group). The ultimate expected outcome is that PRP will prove effective in decreasing post-operative pain and enhancing healing at a faster rate following mandibular third molar extraction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients undergoing removal of mandibular molar , patients with age 18 to 50 years , systematically healthy patients, patients willing to participate in the study.
排除标准
- •Participants who are not ready to participate in the study , Patients with Oral Submucous Fibrosis , Patients with severe medical illness , Active infection present at the extraction site , Participants with age less than 18 years , patients with pathologies involving third molar.
结局指标
主要结局
This study will help us determine the effectiveness of PRP in healing outcome of third molar surgery to reduced swelling and pain
时间窗: Before , 3rd day and 7th day
次要结局
- Clinician can use this technique to overcome the problem of pain and swelling in healing outcome of third molar surgery(Before , 3rd day and 7th day)
研究者
Dr Lahar Patni
KM Shah Dental College