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临床试验/NCT04029532
NCT04029532已完成不适用

Factors Associated With Obesity in Adult Women: Respiratory Exchange Ratio, Heart Rate Variation and Body Image

National Taiwan University Hospital1 个研究点 分布在 1 个国家目标入组 121 人开始时间: 2019年4月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
121
试验地点
1
主要终点
Respiratory exchange ratio (RER)

研究概览

简要总结

The prevalence of obesity all over the world has increased year by year, and how to effectively prevent and treat obesity has become an important health care issue. Many adjustable and nonadjustable causes of obesity have been proposed, such as unbalanced eating habits, lack of physical activity, psychological factors, and genes. The practice guidelines recommended lifestyle modification interventions which include diet control combined with regular exercise as the core treatment for obesity, but the effects on different ethnic groups are not ideal. In order to provide more choices for future weight loss intervention, it would be important to find out more risk factors for obesity. Previous studies have shown that lower sympathetic activity assessed by heart rate variability was related to obesity; obese men have higher respiratory exchange rates which might indicate they are more likely to use carbohydrates as a source of energy, and therefore, fat cannot be effectively consumed and led to an accumulation in the body. Furthermore, previous studies showed that Asians are less satisfied with their body image than other races, and women are more dissatisfied than men. Poor body image will lead to a series of effects, such as changes in eating habits, hormonal changes, depression, etc., eventually forming a vicious circle of obesity. However, most aforementioned Asians in these studies are immigrants living in overseas areas such as the Americas, and cannot fully represent the ethnic groups in Asia. Therefore, the purpose of this study are (1) to investigate the physiological and psychological factors influence obesity in adult women, including respiratory exchange rate, heart rate variability, and body image, and (2) to examine the correlations among these risk factors and different degree of obesity.

详细描述

Methods: This is a cross-sectional design study. Subjects were recruited from Taipei city. Inclusion criteria are women aged between 20 and 50 years old and have willing to participate to this study. Subjects will be excluded as follows: (1) taking medications that affect weight or hormones; (2) fluctuation of weight exceeds 2 kg within 3 months before the enrolled in study; (3) any condition that causes the subject fail to complete the test paper, such as: cognitive problems; (4) diagnosed with mental illness; (5) pregnancy or menopause. The assessments include: obesity-related indicators (height, weight, waist and hip circumference, percentage of body fat), respiratory exchange ratio, heart rate variability, body image (multi-directional self-body relationship questionnaire (MBSRQ), figure rating scale (FRS)), physical activity (Seven-days Physical Activity Recall, 7-d PAR), eating behavior (Three-Factor Eating Questionnaire, revised 18-item, TFEQ-18), and depression (Mongomery-Asberg Depression Rating Scale, MADRS). Statistical analysis will be performed by using SPSS version 18 (SPSS Inc, Chicago: SPSS Inc.), and significant level would be set at 0.05. Analysis of variance (ANOVA) will be used to examine the differences of all measured variables among different degrees of obesity groups. In addition, we will use multiple linear regression analysis to examine whether overweight and obesity are significantly related to respiratory exchange rate, heart rate variability and body image.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
20 Years 至 50 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • 20-50 years old, premenopausal

排除标准

  • Taking medications that affect weight or hormones
  • Fluctuation of weight exceeds 2 kg within 3 months before the enrolled in study
  • Any condition that causes the subject fail to complete the test paper, such as: cognitive problems
  • Diagnosed with mental illness
  • Pregnancy or menopause

结局指标

主要结局

Respiratory exchange ratio (RER)

时间窗: After filling in all questionnaires, lasting 15 minutes.

Ask participants to supine on bed, using a ventilator hood cover upon their head. Measure respiratory exchange ratio for 15 minutes. Device used: Vmax® Encore Metabolic Cart, Carefusion Corporation, Yorba Linda, California (CA). Normal range: 0.7-1.0, greater value indicates more carbohydrates oxidation, while smaller value indicates more fat oxidation.

Heart rate variability (HRV)

时间窗: After measuring respiratory exchange ratio, lasting 15 minutes.

Ask participants to supine on bed for 10 minutes, connect electrodes on their right wrist. Measure heart rate variability for 5 minutes. Device used: SS1C, Enjoy Research Inc., Taiwan. High frequency (HF): greater value indicates active parasympathetic activity. Low frequency-high frequency ratio (LF/HF): greater value indicates active sympathetic activity.

Body image

时间窗: After filling in basic data questionnaire, lasting 10 minutes.

Fill in questionnaire (multi-directional self-body relationship questionnaire (MBSRQ)). There are 69 questions, each question scores 1-5 points. Sum up all points, greater value indicates better body image.

Body image (evaluative component)

时间窗: After filling in multi-directional self-body relationship questionnaire (MBSRQ), lasting 5 minutes.

Figure rating scale (FRS) is used. Nine figures of women (from lean to obese) is provided, participants are asked to choose which figure fits her present and ideal appearance the most. Scoring 1-9 points, greater value indicates poorer body image.

次要结局

  • Body fat percentage(After measuring heart rate variability, lasting 5 minutes.)
  • Physical activity(After filling in body image questionnaire, lasting 5 minutes.)
  • Eating behavior(After filling in physical activity questionnaire, lasting 5 minutes.)
  • Depression(After filling in eating behavior questionnaire, lasting 5 minutes.)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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