The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Resting state functional connectivity changes
研究概览
简要总结
Combined analysis of functional and structural language network changes may be a good model for predicting language outcome.
详细描述
Background & objectives:
Language impairment after aphasic stroke is both common and debilitating. However the mechanisms of language recovery after aphasic stroke is not fully understood. Investigators plan to detect the changes of functional and structural language networks after aphasic stroke by high-resolution MRI.Then Combined analyse functional and structural language network changes, establishing a prediction model for language outcome.
Methods:
The proposed study is a observational trial that will include 50 patients diagnosed with post stroke aphasia from the neurology clinics at The First Affiliated Hospital, Zhejiang University. Aphasia battery of Chinese(ABC) and functional magnetic resonance imaging (MRI) will be performed at acute(~2weeks),subacute(3 months) and chronic phase(6months). Only routine drug therapy will be used.
Relevance:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy right-handed native Chinese speakers with more than 6-year education are recruited as healthy controls.
排除标准
- •Not right-handed;
- •Any use of psychoactive drugs;
- •Less than 6-year education;
- •Not suitable for MRI scan.
结局指标
主要结局
Resting state functional connectivity changes
时间窗: 3 months
The study uses resting state functional MRI(rs-fMRI) to measure changes of functional connectivity across regions after a spontaneous recovery.
次要结局
- Resting state functional connectivity changes(6 months)
- White matter Integrity(6 months)
- Brain response change(6 months)
- Aphasia Battery of Chinese, ABC(6 months)