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临床试验/NCT06867263
NCT06867263尚未招募不适用

Long-term Evaluation of Patients with Fulguration of Posterior Urethral Valve: a Retrospective Cohort Study

Assiut University0 个研究点目标入组 35 人开始时间: 2025年5月1日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
35
主要终点
The rate of spontaneous voiding with insignificant or absent PMR ( according to equation to age ) after one year from fulguration of the PUV.

研究概览

简要总结

To evaluate the long-term outcome after fulguration of the posterior urethral valve.

详细描述

Posterior Urethral Valves (PUV) are the most common cause of lower urinary tract obstruction. More severe forms are detected early in pregnancy (mainly type I), while other forms are usually discovered later in childhood when investigating lower urinary tract symptoms. Bladder dysfunction is common and is associated with urinary incontinence in about 55% (0%-72%). Despite the removal of the obstruction by urethral valve ablation, pathological changes in the urinary tract can occur with progressive bladder dysfunction, which can cause deterioration of the upper urinary tract as well. For this reason, all children with PUV require long-term follow-up, always until puberty. In many cases, the life-long current status is uncertain. The current literature lacks research on long-term outcomes.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

性别
Male
接受健康志愿者

入选标准

  • Patients with fulguration of PUV since 1 year or more

排除标准

  • Patients with neurogenic bladder or meningocele or spina bifida .
  • Patients with renal parenchymal disease and inflammation not related to posterior urethral valve .
  • Diabetic patients .
  • Parental refusal .

结局指标

主要结局

The rate of spontaneous voiding with insignificant or absent PMR ( according to equation to age ) after one year from fulguration of the PUV.

时间窗: One year postoperative

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

keroles Ashraf Soliman

Principal Investigator

Assiut University

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