Candidate Gene Association Study With Injury, Non-Contact Injury, Non-Contact Muscle Injury, Fracture and Apophysitis Injury in Elite Male Youth Football Players
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 123
- 试验地点
- 2
- 主要终点
- Number of non-injured and injured participants with injury risk alleles
研究概览
简要总结
Understanding how candidate genes, previously associated with injury susceptibility, influence the incidence of muscle, bone, ligament, and tendon injuries across the development pathway of elite footballers may provide valuable insight into inherent injury predisposition to support the long-term development of every individual. Therefore, the aim of the present study was to investigate the association between candidate genetic variants and muscle, bone, ligament, and tendon injuries in elite football with sub-analysis of the influence of age and maturation on injury susceptibility.
详细描述
Genetic variants in several candidate genes which code for structural constituents (COL1A1 rs1800012, COL1A2 rs412777, COL5A1 rs12722 and ACTN3 rs1815739), regulatory components (ACE rs1799752, ESR1 rs2234693 and MMP3 rs679620) and transcription factors (VDR rs2228570 and GDF5 rs143383) affecting the form, function and injury susceptibility of muscle, bone, ligament, and tendon tissue will be associated with overall injury, non-contact, bone, ligament, tendon and apophysitis injury risk in elite male youth and adult footballers.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 8 Years 至 40 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Elite Male Footballer Player Registered at Fulham Football Club
排除标准
- •Female no longer registered at Fulham Football Club
结局指标
主要结局
Number of non-injured and injured participants with injury risk alleles
时间窗: 8 Years
Injury, Non-Contact Injury, Non-Contact Muscle Injury, Fracture and Apophysitis Injury
次要结局
未报告次要终点