Effects of multiple cycle of vitamin-A[ 2 lakhs IU] along with oral zinc [50mg] supplementation on adult Bitots spots disappearance - A comparative study visiting Tertiary Care Hospital, AIIMS Deoghar.”

This comparative interventional study will beconducted at the tertiary care center, AIIMS Deoghar, to evaluate the effects of multiple cycles of high-dose vitamin A and oral zinc supplementation on the disappearance of Bitot’s spots in adults. Patients presenting with clinically diagnosed Bitot’s spots will be recruited after obtaining informed consent. Eligible participants will be randomly assigned to two treatment arms. The control group received the conventional therapy comprising vitamin A supplementation at a dose of 2 lakh IU on day 1, day 3, and day 15, along with topical lubricating eye drops. The intervention group received repeated cycles of the same dose of vitamin A (2 lakh IU, on day 1, day 3, and day 15) every three weeks, for a maximum of six cycles, in addition to daily oral zinc supplementation (50 mg twice daily for 3 monts) and lubricating drops. Clinical assessment for Bitot’s spot resolution and any adverse effects will be performed at each follow-up visit. The primary outcome was the rate of disappearance of Bitot’s spots, and secondary outcomes included time to resolution and recurrence rates.