Treatment Response to Rehabilitation in Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 2
- 主要终点
- Neuropsychological test battery, including measures of visual, verbal memory, and problem-solving abilities
研究概览
简要总结
This study will examine the ways in which schizophrenia-related symptoms affect response to a rehabilitation program for people with schizophrenia.
详细描述
Patients with schizophrenia often suffer neurocognitive impairment and psychosocial and vocational difficulties. This study will help identify those patients most likely to benefit from existing behavioral treatments and provide clues for how to modify treatments for those who do not benefit.
Two studies will be conducted. The first will investigate the relationship of symptoms and neurocognitive variables at study entry to psychosocial and vocational status 2 years later. The second study will investigate the relationship of symptoms and neurocognitive variables at study entry to treatment response in patients assigned to either a cognitive remediation track or a computer skills track as part of their rehabilitation treatment.
Both the cognitive remediation and computer skills training programs will last 4 to 6 months. Participants will be assessed pre- and post-treatment. Neuropsychological, psychosocial and vocational status will be measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DSM-IV criteria for schizophrenia or schizoaffective disorder
- •In need of intensive outpatient care
- •Treatment with atypical antipsychotic medication for a minimum of 6 months prior to study entry
排除标准
- •Auditory or visual impairment
- •Mental retardation (IQ less than 70)
- •Traumatic brain injury with loss of consciousness
- •Presence or history of any neurological illness that may affect brain physiology
- •Lack of proficiency in English
- •Concurrent substance abuse and/or dependence
结局指标
主要结局
Neuropsychological test battery, including measures of visual, verbal memory, and problem-solving abilities
时间窗: Measured pre- and post-treatment
Schizophrenia symptoms
时间窗: Measured pre- and post-treament
UCSD Performance-Based Skills Assessment
时间窗: Measured pre- and post-treatment
次要结局
未报告次要终点