The Evaluation of Sublingual Microcirculation To Guide Fluid Resuscitation In Patients With Burn: Prospective Observational Study
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- • Lactate level
研究概览
简要总结
The adequacy of fluid resuscitation will be monitored in burn patients using microcirculation.
Microcirculation camera will be placed on the base of the tongue and at different four quadrants. • Microcirculation parameters at baseline and after 8h , 16h and 24h of fluid resuscitation will be recorded. Fluid resuscitation with lactated ringer according to Parkland formula (4 ml/kg/%TBSA) 50% given during the first 8 hours, with the remainder given during the following 16 hours, will be initiated to maintain a urinary output of 0.5ml/kg/hr.Norepinephrine infusion will be started in case of circulatory failure at a rate of 0.02mic/kg/min to maintain MAP of 65-70mmHg.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age more than 18 years old
- •Burn >20% TBSA
- •Patients with burn admitted within the 1st 6 hours
排除标准
- •Age < 18 years old.
- •Pregnant patients.
- •Patients with severe renal insufficiency.
- •Patients shocked due to other causes as sepsis, hypovolaemia or cardiogenic shock
- •Patients with airway edema that preclude the measurement of sublingual microcirculation
结局指标
主要结局
• Lactate level
时间窗: 24 hours
mmol/L
次要结局
- total vessel density(24 hours)
研究者
Shymaa Fathy
Lecturer of anesthesia and SICU
Cairo University