Study of the Patterns of Microvesicles in the Serum of Participants With Atopic and Non-atopic Asthma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- correlation of microvesicle patterns with atopic state and variation from baseline with episodes of poor asthma control
研究概览
简要总结
The purpose of this study is to determine if a simple blood test can help in disease management, particularly asthma. This will be researched by looking at certain features of the blood and to compare asthmatics without allergies to those that have allergy-induced asthma.
详细描述
A total of 20 participants (men or women) between the ages of 18-50 years with asthma will be enrolled. Participants will remain on their usual asthma treatments as prescribed by their usual asthma care provider. Current asthma treatments and any changes will be recorded at baseline and each subsequent visit. The primary outcome measures are correlation of microvesicle patterns with atopic state and variation from baseline with episodes of poor asthma control. Secondary outcomes include correlations between microvesicle patterns and spirometry, eNO levels, and glucorcorticoid sensitivity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •be between the ages of 18 and
- •have diagnosed asthma.
- •must have less "one pack per day for 10 years" smoking history
排除标准
- •You have had a fever of 100.4º within 24 hours of Visit
- •You are enrolled in another interventional research trial.
- •Have other major chronic illnesses that would interfere with participation in the study.
- •You are pregnant.
- •You chronically use oral corticosteroids.
- •You have taken anti-coagulants, insulin, and any investigative drugs within 2 months.
- •You have the inability or unwillingness to provide consent.
- •Inability to perform aerobic exercise.
- •Inability to perform baseline measurements.
- •Less than 80% completion of screening period diaries.
- •Inability to be contacted by telephone.
- •Intention to move out of the area within 6 months.
结局指标
主要结局
correlation of microvesicle patterns with atopic state and variation from baseline with episodes of poor asthma control
时间窗: 6 months
次要结局
- correlations between microvesicle patterns and spirometry, eNO levels, and glucorcorticoid sensitivity(6 months)
研究者
John Mastronarde, MD
John Mastronarde M.D.
Ohio State University