Interval-training in Type 2 Diabetics - Mechanisms Behind Increased Glucose Disposal and Effects on Systemic Inflammation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Glycemic control
研究概览
简要总结
Interval training is superior to continuous training for improving glycemic control, hereunder glycemic variability and -spikes. However, the underlying mechanisms and the clinical impact is at present unknown.
The overall objective of this project is to determine the mechanisms underlying aeroic interval-training-induced reductions in glycemic variability and -spikes, and the impact on levels of systemic inflammation in type 2 diabetes patients. It is hypothesized that aerobic interval training reduces glycemic variability and -spikes more than continuous training due to larger improvements in both peripheral insulin sensitivity and the mass action effect of glucose. Moreover, it is hypothesized that these reductions in glycemic variability and -spikes also reduces systemic inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes mellitus
- •BMI >18 but <40 kg/m2
排除标准
- •Pregnancy
- •Contraindication to increased levels of physical activity
- •More than moderate levels of physical activity (>90 min/week) of maximally moderate intensity
- •Insulin dependence
- •Thyroid, liver, lung, heart or kidney disease, with the need for treatment
研究组 & 干预措施
Control
Control intervention: Subjects will continue their life unaltered during the 14 days intervention period
干预措施: Control (Behavioral)
Continuous walking
Training intervention: Subjects will perform continuous walking for one hour per day at every weekday during the 14 days intervention period
干预措施: Continuous walking (Behavioral)
Interval Walking
Training intervention: Subjects will perform interval walking for one hour per day at every weekday during the 14 days intervention period. Interval walking will be performed as repeated cycles of three minutes of slow and hree minutes of fast walking during the entire training session
干预措施: Interval walking (Behavioral)
结局指标
主要结局
Glycemic control
时间窗: Change from baseline at 14 days
Glycemic control incl. glycemic variability and -spikes, will be measured with continuous glucose monitoring over 24 hours during standardized dietary intake before and after each intervention.
次要结局
- Urinary isoprostanes as a measure of systemic inflammation(Change from baseline at 14 days)
- Rate of dissappearance during a 2-step (pancreatic + hyperinsulinemic) hyperglycemic clamp, as a measure of glucose effectiveness + insulin sensitivity(Change from baseline at 14 days)
研究者
Anders Rasmussen Rinnov
MD, PhD
Rigshospitalet, Denmark