Attenuation of haemodynamic responses to laryngoscopy and intubation with intravenous dexmedetomidine: A randomised controlled trial on comparison between two doses.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To arrive at an optimal dose of IV dexmedetomidine by comparing different doses of the drug with normal saline in terms of attenuation of haemodynamic stress response to laryngoscopy and endotracheal intubation
研究概览
简要总结
This study is a cross sectional study conducted at St. Johns medical college hospital in the year 2022-2023 .Written informed consent of patient or attenders will be taken prior to participation in the study. General anaesthesia involves placing a tube in your windpipe in order to help you breathe during surgery .This placement of the tube is associated with an increase in your blood pressure and heart rate which can be stressful for your body.
Dexmedetomidine is a drug which has property of good anxiolysis, sedation and analgesic action. It also decreases the dose and Minimum Alveolar Concentration (MAC) value of inhalational anaesthetic agents and prevents postoperative nausea, vomiting and shivering and allows psychomotoric function to be preserved while letting the patient rest comfortably.
This study compares different doses of dexmedetomidine and comparing it with normal saline to arrive at an optimal dose of dexmedetomidine for attenuation of stress response to laryngoscopy and endotracheal intubation. Secondary objective is to assess the sedation after the drug infusion based on Ramsay sedation score.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 59.00 Year(s)（—）
- 性别
- All
入选标准
- •American Society of Anesthesiologists (ASA) Physical Status 1 and 2 Age 18 –59 years Posted for elective surgeries under general anaesthesia.
排除标准
- •Patients who are physically dependent on narcotics Those with a history of bronchial asthma, drug or alcohol abuse.
- •Known drug allergy to either clonidine or dexmedetomidine, Cerebrovascular, neurologic, respiratory or ischemic heart disease (history of angina, previous myocardial infarction) Renal and hepatic dysfunction.
- •Patients on alpha-blockers, antidepressants, anxiolytics, anticonvulsant or antipsychotics Any predicted difficult airway.
结局指标
主要结局
To arrive at an optimal dose of IV dexmedetomidine by comparing different doses of the drug with normal saline in terms of attenuation of haemodynamic stress response to laryngoscopy and endotracheal intubation
时间窗: Recorded at 1, 3 , 5 and 10 min after intubation
次要结局
- To assess the sedation after the drug infusion based on Ramsay sedation score.(Recorded at 1, 3 , 5 and 10 min after intubation)