Relationship Between Acute Lung Injury and Pulmonary Hyaluronic Acid Deposition After Subarachnoid Hemorrhage
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Hyaluronic acid level in bronchoalveolar lavage fluid after SAH
研究概览
简要总结
Acute lung injury is a common complication of subarachnoid hematoma (SAH), and a significant risk factor for death in patients with SAH. Unlike neurogenic pulmonary edema and pneumonia following brain injury, the clinical causes of pulmonary injury after SAH are not intracranial hypertension or pulmonary infection. Its occurrence is influenced by the release of catecholamines, the regulatory function of the hypothalamic-pituitary-adrenal (HPA) axis and systemic inflammatory response, but the specific mechanisms are still unclear. Therefore, delving into the pathological mechanisms of SAH-induced lung injury and developing therapeutic strategies based on the findings is of great importance to improve the prognosis of patients.
Abnormal accumulation of hyaluronic acid in the lungs has been reported to be closely related to the pathological progression of various pulmonary injury diseases, such as chest trauma, pulmonary infection and chronic obstructive pulmonary disease. From this, the present research is aimed to explore the levels and dynamic changes of hyaluronic acid in the bronchoalveolar lavage fluid and blood of patients with acute lung injury following SAH, and to analyze its correlation with the prognosis of pulmonary complications, thereby providing assistance for the clinical diagnosis and treatment of SAH.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 80 years old with independent behavior ability or authorized legal representative.
- •A documented diagnosis of SAH within 5 days.
- •A Hunt-Hess scale of Ⅳ or Ⅴ.
- •Absence of clinical and etiological evidence of pulmonary infection.
排除标准
- •Pregnant or lactating women.
- •Present history of traumatic brain injury or intracranial hemorrhage.
- •Past history of neurological disorders, lung infection within the past six months, cancer, chronic cardiopulmonary diseases, hematological diseases or renal failure.
- •Have participated in clinical trials in the past 4 weeks.
- •The investigator considers that not appropriate for inclusion.
研究组 & 干预措施
Subarachnoid Hemorrhage (SAH)
结局指标
主要结局
Hyaluronic acid level in bronchoalveolar lavage fluid after SAH
时间窗: During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH
Hyaluronic acid level (ng/ml) in bronchoalveolar lavage fluid at the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH
Inflammatory cytokines levels in bronchoalveolar lavage fluid after SAH
时间窗: During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH
Inflammatory cytokines (IL-1β, TNF-α and IL-10) levels (pg/ml) in bronchoalveolar lavage fluid at the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH
次要结局
- Serum hyaluronic acid level after SAH(During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH)
- Serum inflammatory cytokines levels after SAH(During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH)
研究者
Xintong Ge
Director
Tianjin Medical University General Hospital