Serum Asprosin Concentrations in Patients With Periodontitis and Acute Coronary Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Asprosin Levels
研究概览
简要总结
Asprosin, a recently discovered glucogenic adipokine, is mainly synthesized by white adipose tissue and released during fasting. Appetite, glucose metabolism, insulin resistance, cell apoptosis, etc. asprosin is associated with diseases such as diabetes, obesity, polycystic ovary syndrome, and cardiovascular diseases. Periodontal tissue may act as a source of endocrine-like inflammatory mediators (such as TNF-α, IL-6 and IL-1) that are important in periodontal inflammation and can affect glucose and lipid metabolism. Production of TNF-α and IL-6 in adipose tissues strengthens the relationship between cardiovascular diseases and periodontitis. Investigators postulated that asprosin may be a candidate for explaining the triangular relationship between cardiovascular and periodontal disease.
详细描述
Periodontal disease is a chronic, multifactorial, and infectious disease caused by bacteria. It is characterized by the formation of an inflammatory response in the supporting bone and connective tissue against microbial dental plaque, and the nature of the resulting inflammatory response determines the course of periodontal disease. Cardiovascular and periodontal diseases are closely related, presenting a triad association. Asprosin circulates in the blood at nanomolar levels and is taken to the liver, where it activatesinvestigators the G protein-cAMP-PKA pathway, causing rapid glucose release into the circulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For Healthy group
- •All individuals were generally healthy,
- •non-smoking For Myocard Infarctus group
- •patients with ST elevation of Myocardial Infactus
- •patient with less than ten teeth
排除标准
- •Smokers or those with diabetes or other inflammatory disease
- •Pregnant or breastfeeding women
- •None had undergone periodontal therapy and/or antibiotic therapy in the past 6 months.
- •None has a contagious disease such as HIV or AIDS
结局指标
主要结局
Asprosin Levels
时间窗: two weeks
Determination of asprosin levels by making biochemical analyzes from serum
次要结局
未报告次要终点
研究者
Sema Nur Sevinc
Assistant Professor
Ataturk University