NCT04256499已完成不适用
Water Load Test Value for Hyponatremia Due to a Syndrome of Inappropriate Antidiuresis (SIAD)
European Georges Pompidou Hospital1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2001年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Natremia
研究概览
简要总结
Acute water load test has been using to diagnose renal ability to excrete water for decades. Latest recommendations for the diagnosis of hyponatremia do not recommend performing such a test. The investigators aim at, retrospectively, study the value of acute water load test in patients suffering from a syndrome of inappropriate antidiuresis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 18 years old at the time of the test
- •affiliated to a social insurance system
- •water load test performed at the Renal and Metabolic Diseases Unit of the European George Pompidou Hospital, AP-HP, Paris, France
- •between 01/01/2001 and 12/31/2019
排除标准
- •hypernatremia and/or polyuria-polydipsia (diabetes insipidus)
- •hyponatremia due to a tea and toast syndrome and/or a beer potomania
- •hyponatremia due to a high (or normal) osmolality related to diabetes mellitus, hyperproteinemia and/or intoxication
- •chronic kidney disease with an estimated glomerular filtration rate (eGFR) by the MDRD formula <60 mL/min/1.73m2
- •hyponatremia related to thiazides
- •hyponatremia related to an hypovolemic status
- •syndrome of inappropriate antidiuresis related to an endocrine disorder (such as hypothyroidism or adrenal insufficiency)
结局指标
主要结局
Natremia
时间窗: any time after water load test from hour 2 to hour 6
Plasma sodium concentration (abnormal if \<135mM)
次要结局
- Plasma osmolality(any time after water load test from hour 2 to hour 6)
- Excretion of water load(after water load test from hour 0 to hour 6)
- Urine osmolality(any time after water load test from hour 2 to hour 6)
研究者
Jean-philippe Bertocchio, MD, PhD
Principal Investigator
European Georges Pompidou Hospital
研究点 (1)
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