Physiological Response to Salbutamol and Exercise
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Maximal oxygen consumption (VO2max)
研究概览
简要总结
The scope of the study is to investigate the physiological response to salbutamol and exercise. A particular focus is on the metabolic response and amine metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •VO2max of >55 ml/min/kg for men and >50 ml/min/kg for women
- •Body mass index (BMI) < 26
排除标准
- •Chronic use of beta2-agonist or allergy towards beta2-agonist
- •Serious adverse effects to beta2-agonist
- •Chronic disease deemed by the study responsible medical doctor to interfere with any part of the study
- •Chronic use of prescription medicine deemed by the study responsible medical doctor to interfere with any part of the study
- •Pregnancy (for women)
研究组 & 干预措施
beta2-agonist and exercise
Subjects undergo exercise training with administration of salbutamol (800 microgram in 12 hours x 2)
干预措施: salbutamol (Drug)
beta2-agonist and exercise
Subjects undergo exercise training with administration of salbutamol (800 microgram in 12 hours x 2)
干预措施: exercise (Other)
placebo and exercise
Subjects undergo exercise training with administration of sham placebo
干预措施: exercise (Other)
结局指标
主要结局
Maximal oxygen consumption (VO2max)
时间窗: Baseline, 2 weeks, 4 weeks and 6 weeks
Change in VO2max (measured during bike ergometer cycling to exhaustion)
Body composition
时间窗: Baseline, 2 weeks, 4 weeks and 6 weeks
Change in body composition (measured by dual energy x ray absorptiometry)
次要结局
- Salbutamol urine concentration(Before (baseline) as well as 0-1 hours, 1-2 hours, 2-4 hours, 4-8 hours, and 8-16 hours after administration)
研究者
Morten Hostrup, PhD
Associate Professor
University of Copenhagen