A Randomised Controlled Trial Comparing Metoclopramide and Ondansetron to Placebo for the Treatment of Nausea and Vomiting in Adult Emergency Department Patients

Monash Medical Centre0 个研究点目标入组 270 人开始时间: 2009年7月7日最近更新: 2020年1月13日

试验速览

暂无简介。

•Patients >18 years of age with primary or secondary complaint of nausea with or without vomiting who present to the Emergency Department (ED) and require intravenous antiemetic medication.

•Known allergy to any of the trial agents.
•Mild Nausea as rated by patient
•Use of agent with known antiemetic properties in the 8 hours prior to ED presentation (see list of medications with known antiemetic properties).
•Patients who are too unwell to consent or participate i.e. Cardiovascular instability, hepatic failure, renal failure or very severe nausea or vomiting.
•Use of any agent with known antiemetic properties or the administration of normal saline infusion during the ED episode of care (prior to consideration for recruitment).
•Patients with Parkinson disease or restless leg syndrome.
•Patients taking dopamine antagonist.
•Patients with cognitive impairment or language barrier, as these situations would not allow outcome measures to be assessed.
•Patient with motion related nausea or vertigo.
•Pregnancy related nausea or vomiting.
•Patients breast feeding.
•Chemotherapy or radiotherapy induced nausea and vomiting (CINV or RINV).

发起方

Monash Medical Centre