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临床试验/NCT02548273
NCT02548273已完成不适用

Corneal Changes in Diabetics After Phacoemulsification

Jawaharlal Institute of Postgraduate Medical Education & Research0 个研究点目标入组 160 人开始时间: 2013年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
160
主要终点
CHANGE FROM BASELINE IN CORNEAL ENDOTHELIAL CELL DENSITY AT 3 MONTHS

研究概览

简要总结

This study aims to assess the corneal damage after phacoemulsification and to assess the factors causing it in diabetics in comparison with non-diabetics.

详细描述

Title:

Corneal changes in diabetics after phacoemulsification

Introduction:

Cataract is one of the common cause of reversible blindness. In diabetics, Age-related cataract occurs earlier and nuclear cataract is more common and tends to progress rapidly. True diabetic cataract is a rare condition usually occurring in young adults due to the osmotic over-hydration of the lens. Initially a large number of fluid vacuoles appear underneath the anterior and posterior capsules, which is soon followed by the appearance of bilateral snowflake-like white opacities in the cortex.

Diabetic hyperglycemia also inhibits the function of Na+ k+ ATPase activity thereby causing dysfunction of the corneal endothelial cell layer. The endothelial cell morphology is also abnormal in diabetics. Polymegathism and Pleomorphism are noted. The cornea is also found to be thicker in diabetics owing to the slower recovery of corneal edema.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
40 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Diabetic patients with age-related cataract planned for phacoemulsification.

排除标准

  • Patients undergoing cataract surgery (Other than phacoemulsification)
  • High myopia (> -6D)
  • Presence of corneal opacities
  • Presence of pseudoexfoliation
  • Presence of uveitis

结局指标

主要结局

CHANGE FROM BASELINE IN CORNEAL ENDOTHELIAL CELL DENSITY AT 3 MONTHS

时间窗: 3 MONTHS

CHANGE FROM BASELINE IN COEFFICIENT OF VARIATION OF CELL SIZE AT 3 MONTHS

时间窗: 3 MONTHS

CHANGE FROM BASELINE IN CENTRAL CORNEAL THICKNESS AT 3 MONTHS

时间窗: 3 MONTHS

CHANGE FROM BASELINE IN CORNEAL ENDOTHELIAL CELL HEXAGONALITY AT 3 MONTHS

时间窗: 3 MONTHS

expressed as %

次要结局

未报告次要终点

研究者

发起方
Jawaharlal Institute of Postgraduate Medical Education & Research
申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

DR.NIRUBAN.G

Dr.

Jawaharlal Institute of Postgraduate Medical Education & Research

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