Corneal Changes in Diabetics After Phacoemulsification
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 160
- 主要终点
- CHANGE FROM BASELINE IN CORNEAL ENDOTHELIAL CELL DENSITY AT 3 MONTHS
研究概览
简要总结
This study aims to assess the corneal damage after phacoemulsification and to assess the factors causing it in diabetics in comparison with non-diabetics.
详细描述
Title:
Corneal changes in diabetics after phacoemulsification
Introduction:
Cataract is one of the common cause of reversible blindness. In diabetics, Age-related cataract occurs earlier and nuclear cataract is more common and tends to progress rapidly. True diabetic cataract is a rare condition usually occurring in young adults due to the osmotic over-hydration of the lens. Initially a large number of fluid vacuoles appear underneath the anterior and posterior capsules, which is soon followed by the appearance of bilateral snowflake-like white opacities in the cortex.
Diabetic hyperglycemia also inhibits the function of Na+ k+ ATPase activity thereby causing dysfunction of the corneal endothelial cell layer. The endothelial cell morphology is also abnormal in diabetics. Polymegathism and Pleomorphism are noted. The cornea is also found to be thicker in diabetics owing to the slower recovery of corneal edema.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diabetic patients with age-related cataract planned for phacoemulsification.
排除标准
- •Patients undergoing cataract surgery (Other than phacoemulsification)
- •High myopia (> -6D)
- •Presence of corneal opacities
- •Presence of pseudoexfoliation
- •Presence of uveitis
结局指标
主要结局
CHANGE FROM BASELINE IN CORNEAL ENDOTHELIAL CELL DENSITY AT 3 MONTHS
时间窗: 3 MONTHS
CHANGE FROM BASELINE IN COEFFICIENT OF VARIATION OF CELL SIZE AT 3 MONTHS
时间窗: 3 MONTHS
CHANGE FROM BASELINE IN CENTRAL CORNEAL THICKNESS AT 3 MONTHS
时间窗: 3 MONTHS
CHANGE FROM BASELINE IN CORNEAL ENDOTHELIAL CELL HEXAGONALITY AT 3 MONTHS
时间窗: 3 MONTHS
expressed as %
次要结局
未报告次要终点
研究者
DR.NIRUBAN.G
Dr.
Jawaharlal Institute of Postgraduate Medical Education & Research
