Effects of Two Different Ventilation Modes Used in Gynecologic Laparoscopic Operations Performed in Steep Trendelenburg Position on Hemodynamic Parameters
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Measurement of changes in MAP
研究概览
简要总结
Different ventilation modes can be used in laparoscopic surgeries. These surgeries are performed in steep Trendelenburg position with serious hemodynamic disturbances. This study aims to observe the hemodynamic effects of two different ventilation modes in laparoscopic gynecologic surgery performed in steep Trendelenburg position.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women of ASA I and II classification between 18-65 years scheduled for elective gynecologic laparoscopic surgery
排除标准
- •Patient refusal to participate
- •Patients with severe cardiac (congestive heart failure etc) and pulmonary (COPD, pulmonary hypertension) disease (ASA > III)
- •Morbid obesity
- •Negative Allen test
结局指标
主要结局
Measurement of changes in MAP
时间窗: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation
Mean arterial pressure (MAP) (mmHg)
Measurement of changes in heart rate
时间窗: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation
Heart rate (bpm)
Measurement of changes in systemic vascular resistance index
时间窗: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation
Systemic vascular resistance index (dyne x sec/cm2)
Measurement of changes in stroke volume index
时间窗: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation
Stroke volume index (mL/m2)
Measurement of changes in cardiac index
时间窗: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation
Cardiac index L(min x m2)
Measurement of changes in stroke volume variation
时间窗: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation
Stroke volume variation (%)
Measurement of changes in cardiac cycle efficiency
时间窗: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation
Cardiac cycle efficiency (units)
Measurement of changes in aortic dp/dt
时间窗: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation
Aortic dP/dt (mmHg/msec)
次要结局
- Measurement of changes in peak airway pressure(T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation)
- Measurement of changes in mean airway pressure(T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation)
- Measurement of changes in plateau airway pressure(T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation)
研究者
Hakan Yılmaz
Associate Professor
Ufuk University