The Effects of Different Ventilation Modes on Patients With Pulmonary Lobe Resection

Not Applicable

Recruiting

• Conditions: Lung Injury; Lung Inflammation
• Interventions: Procedure: Adopting different ventilation modes during the operation

• Registration Number: NCT06514729
• Lead Sponsor: Mao Enting

Brief Summary

The objective of this study was to discuss the effects of different ventilation modes on patients with plasma inflammatory factor and respiratory function in patients with pulmonary removal.

Detailed Description

Patients who meet the inclusion criteria will be numbered in the order of admission, and a dedicated person will prepare codes and opaque envelopes for random allocation. This study was divided into 3 groups, one groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side, the other groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side; the other groups was ventilation side pressure regulated volume control ventilation+continuous positive pressure ventilation on the non ventilation side.

Study Timeline

• Study Start: 2024-01-01
• Status Verified: 2024-07
• Study First Submitted: 2024-07-17
• Study First Submitted QC: 2024-07-17
• Last Update Submitted: 2024-07-17
• Study First Posted: 2024-07-23
• Last Update Posted: 2024-07-23
• Primary Completion: 2025-05
• Study Completion: 2025-05

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

Comprehensive examination and analysis of imaging, laboratory examination and other comprehensive examinations, the diagnosis is clear, which is in line with lobe resection surgical indications

Age 18-75 years old, the gender is not limited;

ASA grading Ⅰ ~ III level;

It is expected that the single lung ventilation time is ≥1 hours, and ≤3 hours

Exclusion Criteria

Emergency surgery;

There is a taboos on the existence of systemic anesthesia;

There is a history of acute chronic upper respiratory infections in the past January;

Previous bronchial asthma, chronic obstructive pulmonary disease, bronchial dilatation, phthisis ,aspergillosis , acute respiratory distress syndrome or history of respiratory failure;

Merge the function of important organs such as heart, liver, and kidney;

There was a history of chest surgery and the history of trauma;

Preoperative lung function test obvious abnormal abnormal abnormalities (1 second of exhalation (FEV1) <60%);

Patients refuse to participate in the clinical trial

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Group PCV+CPAP	Adopting different ventilation modes during the operation	Ventilation side pressure control ventilation+continuous positive pressure ventilation on the non ventilation side
Group PRVC+CPAP	Adopting different ventilation modes during the operation	Ventilation side pressure regulated volume control ventilation+continuous positive pressure ventilation on the non ventilation side
Group VCV+CPAP	Adopting different ventilation modes during the operation	Ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side

Primary Outcome Measures

Name	Time	Method
Clinical Pulmonary Infection Score	Within 15 days after surgery	The clinical pulmonary infection score index is mainly used to evaluate the severity of pulmonary infection, which involves many factors, including: body temperature, white blood cell count, tracheal secretions, oxygenation, X-ray chest X-ray, and the progress of pulmonary infiltrates. The maximum score is 12 points, and the severity of infection is directly proportional to its score.

Trial Locations

Locations (1)

Affiliated Hospital of Zunyi Medical University; 🇨🇳 Zunyi, Guizhou, China