Different Modes of Ventilation During Cardiopulmonary Bypass

Not Applicable

Completed

• Conditions: Postoperative Pulmonary Dysfunction
• Interventions: Device: Volume controlled ventilation; Device: Pressure controlled ventilation

• Registration Number: NCT03824301
• Lead Sponsor: Ain Shams University

Brief Summary

66 patients divided into 3 groups with different modes of ventilation.

Detailed Description

Sixty-six patients going through open-heart surgeries were included in the study, divided into 3 groups (P: pressure controlled ventilation, V: volume controlled ventilation, C: control) in accordance with the mode of ventilation. Patients studied for chest x-ray, lung ultrasound, arterial oxygen partial pressure to fractional inspired oxygen ratio (PaO2/FiO2), Alveolar-arterial oxygen gradient, static lung compliance and dynamic lung compliance, taken after induction of anesthesia, 1h post cardiopulmonary bypass, 1h after arrival to cardiac surgical unit.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2017-01-22
• Primary Completion: 2018-03-30
• Study Completion: 2018-11-20
• Status Verified: 2019-01
• Study First Submitted: 2019-01-23
• Study First Submitted QC: 2019-01-30
• Last Update Submitted: 2019-01-30
• Study First Posted: 2019-01-31
• Last Update Posted: 2019-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• Patients undergoingvalve surgeries
• Patients undergoing coronary artery bypass grafting surgeries

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Exclusion Criteria

• Emergency cases.
• Off-pump surgeries.
• Patients with chronic lung diseases with forced expiratory volume in first second (FEV1) or forced vital capacity (FVC) less than 40% of the predicted value.
• Massive blood transfusion during surgery.
• Complicated surgeries.
• Redo surgeries.
• Patients with decompensated heart failure prior to surgery.
• Patients refusal

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Volume-controlled ventilation	Volume controlled ventilation	During cardiopulmonary bypass period the patients were ventilated with volume-controlled ventilation
Pressure-controlled ventilation	Pressure controlled ventilation	During cardiopulmonary bypass period the patients were ventilated with pressure-controlled ventilation

Primary Outcome Measures

Name	Time	Method
lung ultrasonography	after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.	Lung ultrasonography to detect any lung changes from baseline or development of consolidation, pulmonary edema or pleural effusion
chest x-ray	after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.	Chest x ray to detect any lung pathology or changes from baseline like pleural effusion, pulmonary edema or pneumonia

Trial Locations

Locations (1)

Ain Shams University cardiothoracic hospital; 🇪🇬 Cairo, Egypt