Effects of Variable Ventilation on Respiratory System of Acute Respiratory Distress Syndrome (ARDS) Patients
- Conditions
- ARDS
- Interventions
- Procedure: Variable ventilation
- Registration Number
- NCT00202098
- Lead Sponsor
- Policlinico Hospital
- Brief Summary
The purpose of this study is to determine the effects of variable ventilation on respiratory system of patients affected by acute respiratory distress syndrome.
- Detailed Description
In this interventional study we want to evaluate the effect of Variable ventilation (1) in patients with ARDS. Patients will be mechanically ventilated with Variable Ventilation (3 step with increased level of variability) and "traditional" CMV, for a total of 4 step. Each step lasts in 60 minutes. During this period we will record the gas exchange parameters and the mechanics of the respiratory system.
1. Arold S, Mora R, Lutchen K, et al. Variable ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury. Am J Resp Crit Care Med 2000; 165: 366-71.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- Patients with ARDS criteria
- Age less than 18 years
- Severe haemodynamic instability
- Patients with clinical or instrumental evidence of flow-limitation (i.e., PEEPi)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 Variable ventilation ALI/ARDS patients
- Primary Outcome Measures
Name Time Method Gas exchange and respiratory mechanics within the first 60 minutes from the ventilatory change
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Policlinico Hospital
🇮🇹Milan, Italy