Influence of Muscle Typology and Training Frequency on Chronic Strength Training Adaptations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Change from baseline isometric muscle strength at 9 weeks
研究概览
简要总结
The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.
Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
The participants don't know their muscle typology during the study. All participants do the same training intervention, no drugs are taken.
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Fast or slow muscle typology
- •18 - 45 years old
- •no strength training experience
排除标准
- •Vegan/vegeterian diet
- •Supplement intake
- •chronic diseases
- •Hypertension,
- •Medication use
- •Coagulation disorder, infectious diseases
结局指标
主要结局
Change from baseline isometric muscle strength at 9 weeks
时间窗: Pre and post 9 weeks training period
Upper legs and upper arms - Biodex
Change from baseline dynamic muscle strength at 6 weeks
时间窗: Pre, mid and post 9 weeks training period
Upper legs and upper arms - strength training devices
Change from baseline muscle volume at 9 weeks
时间窗: Pre and post the 9 weeks training period
Muscle volume of the legs and the upper arms - MRI
Change from baseline dynamic muscle strength at 3 weeks
时间窗: Pre, mid and post 9 weeks training period
Upper legs and upper arms - strength training devices
Change from baseline dynamic muscle strength at 9 weeks
时间窗: Pre, mid and post 9 weeks training period
Upper legs and upper arms - strength training devices
Change in muscle fiber type specific hypertrophy at 9 weeks
时间窗: Pre and post 9 weeks training period
Legs - Biopsy (vastus lateralis)
次要结局
- Change of baseline antropometry at 9 weeks(Pre and post 9 weeks training period)
- Change of baseline skeletal muscle protein content at 9 weeks(Pre and post 9 weeks training period)
- Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks(Pre and post 9 weeks training period)
- Change of baseline histochemistry at 9 weeks(Pre and post 9 weeks training period)
- Change from basline fatigue feeling over 9 weeks training period(Assessed every training during the 9 weeks training period)