Dark Halo a New Biomarker in Macular Neovascularization: a Comparative Study Between ICGA and OCTA
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Dark halo measurement
研究概览
简要总结
The aim of study is to compare the evaluation of dark halo area of macular neovascularization (MNV) between indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA) in order to identify OCTA as effective and useful biomarker in MNV
详细描述
Dark halo is defined as a dark perilesional of flow decrease due to an area of reduced choroidal flow adjacent to the macular neovascularization (MNV).
The detection of MNV vascular details was only possible through invasive dye injection, such as fluorescein angiography (FA) or indocyanine green angiography (ICGA).
Optical coherence tomography angiography (OCTA) is a recent imaging technique that is able to detect the perfusion and non-perfusion areas carefully.
The aim of study is to compare the evaluation of dark halo area of MNV between ICGA and OCTA
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age older than 55 years
- •diagnosis of macular neovascularization
- •absence of previous treatment with anti-Vegf injections
- •absence of other retinal vascular diseases
排除标准
- •age younger than 55 years
- •absence diagnosis of macular neovascularization
- •presence of previous treatment with anti-Vegf injections
- •presence of other retinal vascular diseases
结局指标
主要结局
Dark halo measurement
时间窗: three years
The OCTA and ICGA parameters analyzed are: the area of dark halo (mm2) that surrounds the coroidal neovascularization.
次要结局
未报告次要终点
研究者
Gilda Cennamo
Principal Investigator
Federico II University