Evaluation of the effects of Cornus Mas L. fruit extract capsule on blood glucose and HgbA1C in patients with type 2 diabetes mellitus
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 60
研究概览
简要总结
Background.TheplantCornus masL. (cornelian cherry) is traditionally used as an antidiabetic supplement; however, there is no
related clinical trial. In this study, we evaluated the effects of the fruit extract of this plant on biomarkers of glycemic control in adult
patients with type 2 diabetes.Methods. Sixty patients with type 2 diabetes were randomly assigned to two groups to receive either the
extract or placebo capsules (2 capsules twice daily) for 6 weeks. Each drug capsule contained 150 mg of anthocyanins. Fasting plasma
levels of glucose, insulin, HgbA
1C
, and triglyceride as well as 2-hour postprandial glucose level (2Hpp) were measured before and
after the intervention and finally the mean values were compared between groups.Results. After 6 weeks of intervention, significant
increase in insulin level (1.13 ±1.90 versus-0.643±1.82,
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 80 years（—）
- 性别
- All
入选标准
- •Type 2 diabetes mellitus patients (according to America Diabetes Association ADA); glycosylated hemoglobin levels above 7% and less than 12%; subjects between the ages 18 to 80 years; No alcohol and other drug abuse; Does not change the dose of anti-diabetic medication within 1 month
- •Exclusion criteria: Individuals with a history of diseases; liver and kidney; with the medication use affecting blood sugar levels; pregnant and breastfeeding; hypersensitivity to the drug used in this study; the incidence of diabetic foot ulcers; heart disease, severe systolic blood pressure = 180 and / or pressure diastolic = 110
排除标准
- 未提供