IRCT2012072210361N1已完成未知
The effect of lithium in the functional outcome of post ischemic stroke patients
Deputy of research, Ahvaz Jundishapur University of Medical Sciences0 个研究点目标入组 80 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 50 years 至 90 years（—）
- 性别
- All
入选标准
- •Age among 50 to 90;
- •Sufferer from ischemic stroke (ischemic cerebrovascular accident) including class 1, 4 or 5 of TOAST classification system (i.e. all subtypes of ischemic stroke except than embolic stroke with cardiac origin) in the territory of middle cerebral artery; Maximum time passed from stroke should be equal or less than 48 hours; Consent for participation in study (by patient or his/her first degree relative); No-participation in any other clinical trial; Non-menopause females should not be pregnant or lactating mother.
- •Exclusion criteria: Co-existence of intracerebral hemorrhage (subarachnoid or intraparenchymal) or hemorrhagic conversion during hospitalization; Severe loss of consciousness (score greater than 3 from 1b and 1c questions of NIHSS in the time of entering to the study); Wernicke aphasia (pure or as a part of constellation of other symptoms); Organ failures that may interfere with consumption of lithium, including:
- •Acute or chronic kidney disease (Cr> 1.2)
- •Acute or chronic heart failure (EF < 40% or JVP>9cm or history of orthopnea or nocturnal dyspnea)
- •Acute myocardial infarction (during past 3 months or current hospitalization)
- •Pulmonary edema
- •Respiratory distress that demands ventilator
- •Acute or chronic diarrhea that lead to significant dehydration (dryness of mucosal membrane, sunken eyes or Bun/Cr ratio >20)
- •History of thyroid dysfunction or abnormal TSH
- •Inevitable need to thiazide diuretics, potassium sparing diuretics or ACE inhibitors (but not ARB like Losartan) or calcium channel blockers or need to more than 80mg/day of furosemide); Inevitable need to NSAID except than Aspirin; Non-adherence to physiotherapy and ordered rehabilitation.
排除标准
- 未提供
研究者
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