The Improvement of Intraoperative Neuromonitoring of Recurrent Laryngeal Nerve During Thyroid Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- sugammadex 2 mg/kg allows effective and rapid restoration of neuromuscular function suppressed by rocuronium
研究概览
简要总结
Objectives: The use of neuromuscular blocking agent may interfere with the function of intraoperative neuromonitoring (IONM) in thyroid surgery.
详细描述
An enhanced neuromuscular-blockade (NMB) recovery protocol was investigated in a clinically applied during thyroid neural monitoring surgery. In as subsequent clinical application study, 60 patients who underwent thyroidectomy with IONM followed an enhanced NMB recovery protocol- rocuronium 0.6 mg/kg at anesthesia induction and sugammadex 2 mg/kg at operation start. Train-of-four (TOF) ratio was used for continuous quantitative monitoring of neuromuscular transmission.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy
排除标准
- •Patients with a history of significant cardiac, pulmonary, hepatic, or renal disease, body mass index <18.5 or >35, chronic drug or alcohol abuse
研究组 & 干预措施
Enhanced recovery
rocuronium 2 effective dose at anesthesia induction sugammadex after skin incision and before extubation (total 2 mg/kg iv)
干预措施: sugammadex (Drug)
结局指标
主要结局
sugammadex 2 mg/kg allows effective and rapid restoration of neuromuscular function suppressed by rocuronium
时间窗: 1 month each case
Electromyography signal to assess the quality of neuromonitoring
次要结局
未报告次要终点
研究者
I-Cheng Lu
Doctor
Kaohsiung Medical University Chung-Ho Memorial Hospital