Comparison of the Impacts of Sugammadex With Neostigmine on Patency of Laryngeal Opening (Glottic Aperture Angle)
试验速览
- 阶段
- 不适用
- 入组人数
- 84
- 主要终点
- Angle of vocal folds after administration of sugammadex or neostigmine 2) Degree of change in angle of vocal folds before and after administration of sugammadex or neostigmine
研究概览
简要总结
The aim of this study is to compare the degree of change in the angle of the vocal cords before and after administration of neostigmine or sugammadex. Moreover, we intend to compare the angle of vocal folds after administration of neostigmine or sugammadex.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
triple (Participant, Care Provider, investigator)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients who undergoes elective surgery under general anesthesia with supraglottic airway device.
排除标准
- •Patients under 20 years old
- •Pregnant women
- •Patients who can not read the consent form or are not fluent in Korean (illiterate, foreigner)
- •Patients who refused the clinical trial
- •Patients with dementia or cognitive impairment
- •Patients with neuromuscular disorders impairing neuromuscular blockade
- •Renal dysfunction (estimated Glomerular Filtration Rate less than 30 ml/min/1.73m2)
- •Past history of allergic reactions to neostigmine or sugammadex
- •Patients with ASA class IV or higher
- •Robotic surgery, adenoid or tonsillectomy
- •Patients with moderate or severe asthma, pulmonary function tests with forced expiratory volume for 1second of 1 liter or less, patients with upper respiratory infection symptoms within 2 weeks before surgery, current smokers (within 1 month of smoking cessation is included.)
研究组 & 干预措施
Sugammadex
Administration of Sugammadex
干预措施: Sugammadex (Drug)
Neostigmine
Administration of Neostigmine
干预措施: Neostigmine (Drug)
结局指标
主要结局
Angle of vocal folds after administration of sugammadex or neostigmine 2) Degree of change in angle of vocal folds before and after administration of sugammadex or neostigmine
时间窗: 1-2 minutes after drug administration (inhalation, exhalation)
Degree of change in angle of vocal folds before and after administration of sugammadex or neostigmine
时间窗: 1) Just before drug administration 2) 1-2 minutes after drug administration (inhalation, exhalation)
次要结局
- Time to recover from spontaneous breathing(immediately after drug(sugammadex or neostigmine) administration)
- Time to extubation(immediately after drug(sugammadex or neostigmine) administration)