NL-OMON54037招募中不适用
Identification and characterization of non-alcoholic fatty liver disease in primary care. - NAFLD primary care
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,468
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Able to understand and sign the informed consent
- •Able to speak Dutch
- •Between 18-80 years
- •BMI >25 kg/m²
- •Having one of the following conditions: 1)overweight, 2) obesity, 3) type 2
- •diabetes mellitus, 4) cardiovascular diseases (hypertension, atherosclerosis,
- •angina pectoris, ischaemic heart condition, cerebrovascular condition)
- •Additional inclusion criteria valid only for the other food additives and
- •limonene breath test
- •All those listed in the main protocol +
- •NAFLD F2-F3-F4 fibrosis stage (FibroScan >= 7.5 kPa)
- •Capability to complete an overnight fasting (>=10h)
- •Willingness to share data with Owlstone Medical LTD.
排除标准
- •Excessive alcohol use
- •o more than 20 g/day for women and 30g/day for men
- •o >2 glasses alcohol/day for women and >3 glasses for men
- •Other liver diseases: Hepatitis B virus, Hepatitis C virus, autoimmune
- •hepatitis, primary biliary cirrhosis, hemochromatosis, Wilson*s disease, Alpha
- •1 antitrypsin deficiency
- •Secondary causes for steatosis: disorders of lipid metabolism, HCV Genotype 3,
- •total parental nutrition, severe surgical weight loss, medications (amiodarone,
- •tamoxifen, methotrexate, corticosteroids and HAART), lean steatosis, Celiac
- •disease, environmental toxicity
- •Pregnancy and breastfeeding.
- •A history of bariatric surgery.
- •Diagnosis of liver cirrhosis and/or hepatocellular carcinoma.
- •Current diagnosis of extrahepatic malignancy(s) or prior diagnosis within last
- •Individuals about to undergo a surgery or otherwise medical procedure that will
- •interfere with data collection and analyses planned within the current cohort,
- •will initially be excluded from participation, but are offered the opportunity
- •to participate at a later moment in time (e.g., after 3 months are myocardial
- •infarction patients are eligible for participation).
- •Additional inclusion criteria valid only for the other food additives and
- •limonene breath test
- •All those listed in the main protocol +
- •Inability to complete the breath sampling procedure
- •Known carrier of a-1 Antitrypsin deficiency
研究者
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