IRCT20211202053252N2尚未招募3 期
A comparison of silymarin vs benzydamine rinse in the prevention of radiation-induced oropharyngeal mucositis in head and neck cancers: A randomized controlled trial
适应症
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 98
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 no limit（—）
- 性别
- All
入选标准
- •Age over 18 years old
- •Any ECOG performance status
- •Head and neck cancer patient
- •Any setting of radiation (i.e. definitive, neoadjuvant, adjuvant)
- •Receiving at least 50 Gy radiation to 2 out of 4 subsite of the head and neck, including oral cavity, Oropharynx, hypopharynx, and the larynx
- •More than 2 cm of irradiated mucosal surface in any head and neck subsite
排除标准
- •History of severe allergy to silymarin, benzydamine or other NSAIDs
- •Narcotic use in the last month (even once)
- •History of radiation therapy to the same target areas
- •Presence of mucositis on admission
- •History of dry mouth
- •Proven dementia or history of uncontrolled psychiatric disease
- •Malnutrition
研究者
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