A prospective, interventional, double- blind randomized controlled study of efficacy of oral tranexamic acid in patients with facial melasma - TXA

KJSomaiya medical college and research centre0 个研究点目标入组 130 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•All consenting male and female patients diagnosed clinically with melasma being defined as having acquired hyperpigmentation on the face, irregular light to gray brown macules or patches located on sunâ??exposed skin commonly affecting the cheeks, forehead, upper lip, nose and chin symmetrically attending the out-patient clinic at Department of Dermatology, Venereology and Leprosy of our tertiary care hospital.
•b)Age > 18 years
•c)Absence of other confounding inflammatory dermatoses (eg. Exogenous ochronosis, Acanthosis nigricans, post inflammatory hyperpigmentation, Pigmented cosmetic dermatitis, Actinic lichen planus, malar rash, etc.)

•EXCLUSION CRITERIA:
•a)Patients with melasma on neck and/or forearms attending the out-patient clinic at the Department of Dermatology, Venereology and Leprosy.
•b)Pregnancy and lactation,
•c)Any chronic medical illness,
•d)History of thrombosis, abnormal bleeding profile,
•e)Any medical treatment for melasma within 1 month of entry,
•f)Skin resurfacing by dermabrasion, chemical peels, and facial laser within the preceding 9 months,
•g)Hypersensitivity to TXA,
•h)Abnormal bleeding time, clotting time or platelet count
•i)History suggestive of Acquired defective colour vision
•j)Refusal to allow photographs and
•k)Failure to finish the whole period of study would be excluded from the study.

发起方

KJSomaiya medical college and research centre