Comparison of Diluted vs Concentrated Regional Citrate Anticoagulation in Continuous Renal Replacement Therapy: A Quasi-experimental Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 2
- 主要终点
- Dialysis flow
研究概览
简要总结
The investigators designed a monitoring and control table of a citrate treatment on a specific monitor. This is the Baxter "Prismaflex" monitor, with 8.2 software version. Dialysis bath liquids marketed by Baxter: Biphozyl are used. Citrate liquid (1:18) Regiocit is used.
The dialysis treatment monitor (CVVHD) is programmed, with a blood / citrate pumps at a rate of 1:10 (1 ml / min of blood: 10 ml / h of dialysis fluid) The starting dose of citrate will be 3.5 mmol / l and the calcium compensation will be 100% Working hypothesis: The patient undergoing citrate anticoagulation according to the designed algorithm will respond with ion stability and pH during the treatment, in addition to achieving an effective cleaning process.
详细描述
Study design: quasi-experimental design. two groups:
- Usual protocol with Multifiltrate monitor and citrate (136 mmol/l)
- Intervention group. New protocol with Prismaflex monitor and citrate (18 mmol/l)
Study population Inclusión/exclusion criteria:
Adult patients (regardless of their underlying pathology), who develop acute renal failure, admitted to the ICU of St Pau Hospital with the Intensive Medicine medical team, who require citrate anticoagulation in continuous dialysis therapy and are treated with Baxter "Prismaflex" monitor.
Patients who meet the criteria described above will be followed up in this study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (regardless of their underlying pathology), who develop acute renal failure, admitted to the ICU of St Pau with the medical team of Intensive Medicine, who require anticoagulation with citrate in continuous dialysis therapy and are treated with the Baxter monitor.
排除标准
- •parenteral nutrition
- •pregnancy
- •cardiac surgery
- •coronary patients
结局指标
主要结局
Dialysis flow
时间窗: 6 hours
Speed at which the dialysis fluid pump is programmed in the circuit and measured in milliliters / hour
Blood flow
时间窗: 6 hours
Speed at which the blood pump is programmed in the dialysis circuit and measured in milliliters / min
Calcium dose
时间窗: 6 hours
Amount of calcium that is replenished to the patient when the dialyzed blood is returned. It is measured in%.
Citrate dose
时间窗: 6 hours
Relationship that exists between the liquid we infuse (which contains 18mmol / L citrate) and the blood pump. It is measured in mmol citrate / liter of blood
次要结局
- Arterial pH(6 hours)
- Total Ca / Ionic Ca Ratio(24 hours)
- Magnesium(24 hours)
- Sodium(24 hours)
- Creatinine(24 hours)
- Total calcium(6 hours)
- Match(24 hours)
- Potassium(24 hours)
- Urea(24 hours)
- INR(24 hours)
- Filter operating hours(number of hours)
- Arterial bicarbonate(6 hours)
- Lactate(24 hours)
- Post-filter ionic calcium(6 hours)
- Ionic Calcium Patien(6 hours)