Neurohumor Mechanism of Deferent Frequency Transcutaneous Electrical Acupoint Stimulation(TEAS): A Prospective, Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 81
- 主要终点
- Plasma concentration of epinephrine(ng/L)
研究概览
简要总结
The purpose of this study is to explore the neurohumoral mechanism of deferent frequency TEAS pretreatment.
详细描述
Patients were randomly assigned to three groups, receiving TEAS 30min before anesthesia. The frequency of high frequency group is set to 10/50HZ, low frequency group is 2/10HZ, and the fake stimulation group only attach electrodes without electric current. Acupoint selection is bilateral Neiguan points(PC6). Venous blood is collected 4ml before and immediately after TEAS respectively. Heart rate variability is monitored continuously during the 30min TEAS. The adverse events recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18yrs-65yrs
- •Scheduled for elective operation under general anesthesia
- •BMI 18-30kg/m2
- •Informed consented
排除标准
- •Contraindications to TEAS
- •Communication difficulty with researchers
- •Addicted to alcohol, analgesics or other drugs
- •Cardiac insufficiency or high blood pressure without controlled
- •Hepatic or renal dysfunction
- •Participate in the other clinical trial 3 month before the enrollment
结局指标
主要结局
Plasma concentration of epinephrine(ng/L)
时间窗: change of TEAS 0 and 30 minutes
Plasma concentration of norepinephrine(ng/L)
时间窗: change of TEAS 0 and 30 minutes
次要结局
- Heart rate variability(During 30min TEAS)
- plasma concentration of glucocorticoid(μg/L)(change of TEAS 0 and 30 minutes)
- plasma concentration of aldosterone(ng/L)(change of TEAS 0 and 30 minutes)
- plasma concentration of renin(ng/L)(change of TEAS 0 and 30 minutes)
- plasma concentration of β-endorphin(ng/L)(change of TEAS 0 and 30 minutes)
研究者
wangqiang
Doctor
Xijing Hospital