Development of a Tool to Assess Receptive Prosody in the Aftermath of a Right Stroke: Use of the Inverse Correlation Paradigm
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Evolution of the inverse correlation task at the beginning and at the end of participation
研究概览
简要总结
Following a right stroke, more than half of the patients present a communication disorder. These disorders can notably concern prosody. Nevertheless, these remain relatively poorly assessed and characterized. Prosodic alterations in comprehension can result in a disruption of social cognition with potentially important consequences in terms of functional outcome and quality of life of patients. In clinical practice, the investigators do not have a tool that allows us to finely assess these disorders.
Studies in healthy subjects using a processing algorithm capable of arbitrarily manipulating the pitch dynamics of recorded voices have revealed that there are stable internal representations for prosody processing. Initial pilot results show that this method can be used in a clinical context and can indeed identify and accurately measure perceptual processing deficits in prosody following a right stroke. It is necessary to continue the study of this approach with a larger number of subjects in order to have normative data and validate the diagnostic properties of this approach.
详细描述
The aim of this project is to study impairments of speech prosodic perception using a novel data-driven psychoacoustic technique, reverse correlation.
The project will, first, conduct a prospective diagnostic study on N=150 stroke patients and controls, in order to evaluate the relevance of reverse-correlation data as a marker of prosodic impairments. Second, the project will use this novel patient data for theoretical investigations such as lesion-symptom mapping, in order to better understand how prosodic processing differs between patients and controls. Finally, the project will develop a novel mobile audio-health platform to facilitate the adoption of the reverse-correlation procedure in clinical practice and to collect remote patient data to assist medical decision-making.
The rationale of the reverse correlation technique is to uncover a listener's mental representation of certain prosodic patterns (e.g. the different intonation of "really?" vs "really!") by analyzing a large set of responses to random stimuli.
The expected results of the project are threefold: (1) the investigators will provide a new tool able to diagnose stroke-related prosody impairments beyond existing gold standards, (2) the investigators will provide a finer characterization of symptomatological profiles in these patients and (3) the investigators will provide a new prognosis metric, implemented in a mobile application, to quantify how well a patient reacts to speech therapy day after day.
The project will both further our understanding of aprosodia and provide new clinical tools to improve its diagnosis and rehabilitation. Beyond stroke, the project will also provide a case-study for the application of reverse-correlation to general speech therapy practice, benefiting patients across the whole spectrum of hearing impairments.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •->Inclusion Criteria: Inclusion criteria for patients
- •with a right supratentorial stroke (1st clinical episode of deficit) confirmed on imaging and less than 1 year old at the time of inclusion
- •right-handed
- •male and female over 18 years of age
- •french mother tongue
- •affiliated or beneficiary of a social security plan
- •free, informed and written consent signed
- •Inclusion criteria for control subjects:
- •no known history of stroke
- •right-handed
- •over 18 years of age and matched with a case on age (plus or minus 10 years)
- •french mother tongue
- •affiliated or beneficiary of a social security plan
- •free, informed and written consent signed
排除标准
- •Non-inclusion criteria for patients and controls subjects
- •comprehension disorders: score less than 10/15 on the BDAE (Boston Diagnostic Aphasia Examination) command execution test
- •known dementia
- •illiteracy
- •severe dysarthria
- •psychiatric history requiring hospitalization in a specialized environment for more than two months
- •history of brain injury
- •major visual or auditory perceptual disorder (hearing loss greater than 40 dB HL)
研究组 & 干预措施
Patients
Patients with right stroke consecutively recruited according to inclusion and non-inclusion criteria
干预措施: understanding of prosody (Other)
Healthy volunteers
Healthy volunteers with no known history of stroke
干预措施: understanding of prosody (Other)
结局指标
主要结局
Evolution of the inverse correlation task at the beginning and at the end of participation
时间窗: 6 months
The inverse correlation task that will be proposed in the study consists of presenting pairs of the word "really" with random variations in the height (F0) of the bounds of the six 71 ms segments of the word, asking them to distinguish within each pair which is the more interrogative.
次要结局
- Assessment of musical perception(Inclusion, after 3 months and 6 months)
- Assessment of hearing acuity(Inclusion, after 3 months and 6 months)
- Assessment of depression(Inclusion, after 3 months and 6 months)
- Event-Related Potentials (EEG)(Inclusion, after 3 months and 6 months)
- Assessment of anxiety(Inclusion, after 3 months and 6 months)
- Assessment of central auditory disorders(Inclusion, after 3 months and 6 months)
- Assessment of auditory attention(Inclusion, after 3 months and 6 months)