Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia

Not Applicable

Completed

• Conditions: Aphasia
• Interventions: Behavioral: speech therapy

• Registration Number: NCT01163461
• Lead Sponsor: VA Office of Research and Development

Brief Summary

This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking. The name of this disorder is called 'aphasia'. Individuals who participate in this study will receive 60 hours of therapy for free (2 hours/day, 5 days/week, 6 weeks).

Detailed Description

The study design was a single group (n=26) with repeated testing (3 times) pre- and post-treatment. All participants received the same treatment protocol (described in detail in Appendix A and in Minkina et al. (under review)). In order to control for improvement in language function related to passage of time, and for the effect of repeated exposure to outcome measures, individuals were randomly assigned to one of two conditions: delayed treatment or immediate treatment (Figure 2). Participants who were randomized to the delayed group received repeated testing three times before and three times after a six-week delay. During the delay phase they were permitted to participate in usual speech-language care (e.g., conversation groups and individual therapy).

Standardized assessments and outcome measures (described in detail below) were administered prior to the start of treatment (for both immediate and delayed groups), at the end of the delay phase (delayed group only), immediately after treatment termination, and at three months post-treatment.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2010-07-14
• Study First Submitted QC: 2010-07-14
• Study First Posted: 2010-07-15
• Study Start: 2010-09-01
• Primary Completion: 2013-06-30
• Results First Submitted: 2014-09-29
• Study Completion: 2014-09-30
• Results First Submitted QC: 2015-07-09
• Results First Posted: 2015-07-16
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-30
• Last Update Posted: 2017-08-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• left hemisphere stroke
• monolingual English speaking
• right handed
• presence of aphasia

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Exclusion Criteria

• preexisting neurological condition

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Immediate Treatment	speech therapy	individuals will receive 60 hours of speech therapy
Delayed Treatment	speech therapy	individuals will receive 60 hours of speech therapy after 6 week delay period

Primary Outcome Measures

Name	Time	Method
Speech Production	Baseline to one week post treatment termination and three months post treatment termination	percent change in the number of untrained words spoken correctly

Trial Locations

Locations (1)

VA Puget Sound Health Care System Seattle Division, Seattle, WA; 🇺🇸 Seattle, Washington, United States