Brain Blood Flow Response to Hypercapnia in Healthy Adults: The Effect of Age and Sex
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Middle Cerebral Artery Blood Flow Measurement
研究概览
简要总结
Baseline cerebral blood flow through the middle cerebral artery (MCA) and cerebral vasodilator response of the MCA to inhaled carbon dioxide (CO2) will be measured in young women, young men, older women, and older men using Magnetic Resonance (MR) imaging and transcranial Doppler ultrasound (TCD). Data collection techniques will be compared.
详细描述
The investigators have recently shown that cerebral blood flow responses to chemical stimuli are reduced in healthy older adults. The investigators also have preliminary data suggesting that sex differences in cerebrovascular regulation exist. The overall goal of this application is to extend on the investigators previous studies by employing advanced neuroimaging techniques to enhance the investigators understanding of neurovascular coupling in healthy aging. This study will collect clinically significant data with implications for the future risk of cognitive decline and Alzheimer's disease.
The research aims are:
- To determine the effect of age and sex on baseline cerebral blood flow through the middle cerebral artery (MCA).
- To determine the effect of age and sex on cerebral vasodilator responses.
- To determine if the cerebrovascular responses measured by transcranial Doppler ultrasound (TCD) are associated with the cerebrovascular responses measured by Magnetic Resonance (MR) imaging.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between 20-34 or 50-69 years
- •Body mass index <34 kg/m2
排除标准
- •Current smoker
- •History or evidence of: hepatic disease, renal disease, hematological disease, peripheral vascular disease, stroke/neurovascular disease, diabetes, hypertension
- •Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)
- •Older females only: subject is not post-menopausal
结局指标
主要结局
Middle Cerebral Artery Blood Flow Measurement
时间窗: 75 minutes
Utilize the TCD and MR imaging to measure middle cerebral artery blood flow in the brain while the participant is at rest.
Middle Cerebral Artery Blood Flow Reactivity to Hypercapnia
时间窗: 75 minutes
Utilize the TCD and MR imaging to measure middle cerebral artery blood flow reactivity to hypercapnic gas.
次要结局
未报告次要终点