Eye Gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases: Links With Neuropsychiatric Disorders (EYE-ToM Study)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 74
- 主要终点
- Eye gaze strategies (duration of eye fixation) during Facial emotion recognition (FER)
研究概览
简要总结
It is commonly admitted that social cognition impairment, like deficit in facial emotion recognition or misinterpretation of others' intentions (Theory of Mind), are associated with social behavior disorders.
This kind of disorders are observed in Fronto-Temporal Dementia (FTD), Alzheimer's Dementia (AD) and Parkinson's Disease (PD), with severe deficits in FTD and lighter deficits in AD and PD.
One explanation might be that patients apply inappropriate visual exploration strategies to decode emotions and intentions of others.
This study aims to test this hypothesis and further to analyse whether different patterns emerge from these pathologies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalized or coming to perform a consultation, for whom an Eye-Tracking examination is indicated as part of routine care.
- •Sufficient written and oral expression in French.
- •Written informed consent signed by the patient.
- •For the control group: No cognitive impairment (non pathological MMSE (according to age, gender and socio-cultural level), no neurological history, and no psychiatric history (especially anxiety and depressive disorders).
- •For the FTD group: Patient diagnosed according to revised Rascovsky et al. 2011., no neurological history (excepted diagnosed FTD), and no psychiatric history (excepted those related to diagnosed FTD).
- •For the AD group: Patient diagnosed according to DSM-IV-TR criteria, no neurological history (excepted diagnosed AD), and no psychiatric history (excepted those related to diagnosed AD).
- •For the PD group: Patient diagnosed according to NINDS criteria, no neurological history (excepted diagnosed PD), and no psychiatric history (excepted those related to diagnosed PD).
排除标准
- •General anaesthesia within 3 months.
- •Ophthalmological problems preventing a video-oculography examination.
- •Oculomotor disorders such as "fixation disorders" or "ocular tracking disorders".
- •Cognitive disorders of the type: visual agnosia, visuo-spatial disorder, visuo-perceptual disorder or aphasia.
- •History of stroke.
- •History of alcohol or drug abuse.
结局指标
主要结局
Eye gaze strategies (duration of eye fixation) during Facial emotion recognition (FER)
时间窗: Baseline
Comparison of gaze patterns between control group and pathological groups, during Facial emotion recognition tasks. Evaluation criteria: duration of eye fixations. Eye movements were recorded with an eye-tracking device. FER was assessed using some pictures from the Ekman Faces task (1976).
Eye gaze strategies (duration of eye fixations) during Affective Theory of Mind (ToM)
时间窗: Baseline
Comparison of gaze patterns between control group and pathological groups, during Affective ToM task. Evaluation criteria: duration of eye fixations. Eye movements were recorded with an eye-tracking device. Affective ToM was assessed using the " Reading the Mind in the Eyes " test (Baron-Cohen 2001).
Eye gaze strategies (number of eye fixation) during Affective Theory of Mind (ToM)
时间窗: Baseline
Comparison of gaze patterns between control group and pathological groups, during Affective ToM task Evaluation criteria: number of eye fixation. Eye movements were recorded with an eye-tracking device. Affective ToM was assessed using the " Reading the Mind in the Eyes " test (Baron-Cohen 2001).
Eye gaze strategies (number of eye fixation) during Facial emotion recognition (FER)
时间窗: Baseline
Comparison of gaze patterns between control group and pathological groups, during Facial emotion recognition tasks. Evaluation criteria: number of eye fixation. Eye movements were recorded with an eye-tracking device. FER was assessed using some pictures from the Ekman Faces task (1976).
Eye gaze strategies (response times) during Affective Theory of Mind (ToM)
时间窗: Baseline
Evaluation criteria: time to answer for each picture (in second). It was recorded using the eye-tracking device. Affective ToM was assessed using 36 pictures from the " Reading the Mind in the Eyes " test (Baron-Cohen 2001), with a maximum of 8 seconds of response time per picture.
Eye gaze strategies (response times) during Facial emotion recognition (FER)
时间窗: Baseline
Comparison of gaze patterns between control group and pathological groups, during Facial emotion recognition tasks. Evaluation criteria: time to answer for each picture (in second). It was recorded using the eye-tracking device. Facial emotion recognition was assessed using 28 pictures from The Ekman Faces task (1976), with a maximum of 8 seconds of response time per picture.
次要结局
- Affective ToM performances(Baseline)
- Facial emotion recognition (FER) performances(Baseline)
- Behavioral disorders.(Baseline)