DRKS00015152已完成未知
Effect of physical activity on brain-derived neurotrophic factor – Association with cognitive dysfunction in depression. An explorative study - BDNF-Pilot Study
niversitätsklinikum Heidelberg, Zentrum für psychosoziale Medizin, Klinik für allgemeine Psychiatrie, Arbeitsgruppe Neurokognition0 个研究点目标入组 41 人开始时间: 2018年8月3日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 41
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized controlled study
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 60 Years（—）
- 性别
- All
入选标准
- •(1)Outpatients with a current or past-time diagnosis of major depressive disorder
- •(2)Age between 18 and 60 years
- •(3)IQ>80 according to the Mehrfachwahl-Wortschatztest B (MWT-B)
- •(4)Clinically stable patients who are able to provide informed consent
- •(5)Subjective Cognitive Complaints
排除标准
- •(1)Psychiatric co-morbidities as identified by mini international neuropsychiatric interview: current substance (alcohol or drug) abuse and dependence, current or lifetime psychotic disorder and mania, current anorexia, bulimia, PTSD, and panic disorder
- •(2)Reported current or chronic neurological disorders
- •(3)Patients with Hamilton Rating Scale for Depression (HAMD-21) scores = 20 will be excluded to avoid confounding with severe depressive symptoms.
- •(4)Physical fitness: Patients with somatic conditions presenting a risk to the graded exercise test will be excluded, e.g., unstable angina pectoris, symptomatic arrhythmia, symptomatic aortic stenosis, heart failure, acute pulmonary embolism, acute myocarditis, acute pericarditis, acute aortic dissection, high grade coronary artery disease, uncontrolled hypertension (RR>200/110mmHg), hypertrophic cardiomyopathy, endocarditis, symptomatic congenital and acquired heart defects. Furthermore, patients who cannot sufficiently participate in the graded exercise test due to health issues, e.g. COPD, severe asthma, current severe allergies, severe obesity (bodyweight >180kg, weight limit of the stationary bicycle), orthopedic disabilities will be excluded.
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