Postprandial Effects of Chestnuts on Glycaemic Response: a Cross-over Trial in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Postprandial blood glucose incremental area under the curve (iAUC)
研究概览
简要总结
Nut consumption is known to improve health outcomes, such as reducing the risk of chronic diseases like diabetes, cognitive impairment, and cardiovascular diseases. While most research has focused on walnuts and almonds, there is limited information on the health benefits of chestnuts. Chestnuts are unique among tree nuts due to their high starch and fibre content, along with vitamins E and C, minerals (potassium, phosphorus, magnesium), and polyphenols.
Evidence from in vitro and animal studies suggests that chestnuts may positively affect health by regulating the gut microbiome, lowering the glycaemic index, and providing antioxidant benefits. The food industry is also exploring new uses for chestnuts, particularly in gluten-free products, due to their nutritional benefits and good taste. Nonetheless, no research has investigated the health effects of chestnuts in humans. By addressing this gap in the literature, the study may lead to the development of new dietary strategies for improved health outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults 18-65 years old
- •Available to attend two testing sessions at the research facility
排除标准
- •Allergy to nuts and/or gluten,
- •BMI<18.5 or ≥30 kg/m2,
- •Fasting glucose >5.6 mmol/L, presence of diabetes and/or taking anti-diabetic medication
- •Serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery,
- •Cardiovascular disease
- •Pregnant or breastfeeding women
- •Presence of implanted cardiac defibrillator
研究组 & 干预措施
Control meal
Participants will receive an isocaloric baked meal without chestnut flour.
干预措施: Control meal (Other)
Chestnut meal
Participants will receive an isocaloric baked meal with chestnut flour.
干预措施: Chestnut meal (Other)
结局指标
主要结局
Postprandial blood glucose incremental area under the curve (iAUC)
时间窗: Three hour blood glucose iAUC will be calculated from nine time points (0, 15, 30, 45, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.
Difference in postprandial blood glucose iAUC
Postprandial plasma insulin incremental area under the curve (iAUC)
时间窗: Three hour insulin iAUC will be calculated from seven time points (0, 30, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.
Difference in postprandial plasma insulin iAUC.
次要结局
- Postprandial glucose concentration(Glucose concentration will be measured at nine time points (0, 15, 30, 45, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.)
- Postprandial insulin concentration(Insulin concentration will be measured in finger prick blood samples at seven time points (0, 30, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.)
- Time to peak glucose(Three hours)