Study of Metabolic Connectivity in Drug-resistant Temporal Epilepsy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Metabolic connectivity
研究概览
简要总结
18F-Fluoro-deoxy-glucose (18F-FDG) positron emission tomography (PET) has a high sensitivity for temporal lobe epilepsy (TLE), the most common form of focal epilepsy, with a detection range of 86-90% . Therefore, 18F-FDG PET is a useful tool to identify the epileptogenic zone (ETZ) in the inter-ictal phase of drug-resistant temporal epilepsy during pre-surgical evaluation . Based on stereotactic electroencephalography (SEEG) findings, a correspondence between electrical data and metabolic changes on PET was found at the group level by identifying four different patterns of TLE . As expected, hypometabolism was not limited to the EZ defined by SEEG, but underlay broader epileptic networks . Because of the different electroclinical presentations of TLE, 18F-FDG PET appears to be a very useful tool in these temporal epilepsies. Indeed, it has been recently demonstrated that a gradient of PET hypometabolism from the uninvolved area to the spreading area, then to the epileptogenic area and to the lesion area is observed with consequently a good performance of 18F-FDG PET in defining the EZ .
Therefore, it is interesting to study PET metabolism as a network and not as a combination of regional metabolic measures in epilepsy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 56 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with drug-resistant temporal epilepsy with an accurate diagnosis on SEEG
- •Patients with epilepsy who have had a PET/CT scan with 18F-FDG as part of a pre-operative assessment
- •Person having received complete information on the organization of the research and not having objected to the use of these data;
- •Patients affiliated to a social security system
排除标准
- •Person who has not received full information on the organization of the research and who has opposed the use of this data
- •A person of full age who is the subject of a legal protection measure (guardianship, curatorship, safeguard of justice).
- •A person of full age who is unable to give consent and who is not subject to a legal protection measure
结局指标
主要结局
Metabolic connectivity
时间窗: 1 month
Metabolic connectivity of hypometabolic clusters in each temporal epilepsy subgroup defined by IRCA (interregional correlation analysis) and graph theory
次要结局
未报告次要终点
研究者
Antoine VERGER
MD, PhD
Central Hospital, Nancy, France