Use of BRASS in Sedated Critically-ill Patients as a Predictable Mortality Factor
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- CHU de Reims
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- mortality within 28 days after ICU admission
研究概览
简要总结
Sedation is used for 30 to 70 % of all intensive care unit (ICU) patients. Deep sedation can be used for lot of disease like acute respiratory distress syndrome, septic shock.
Deep sedation was defined by RASS (Richmond Assessment Sedation Scale) below -3.
Deep sedation can be associated with increased mortality, length stay, duration of mechanical ventilation, acute brain dysfunction.
The french exploration neurologic group in ICU developed a score used Brainstem response patterns in patient deeply sedated by midazolam and showed that a high BRASS score is associated with high mortality at day 28.
The investigators think that BRASS score isn't associated with the medication used for sedation.
In this study the investigators included all patients sedated independently of medication used for sedation, we also excluded patient with neurologic disorder.
The main objective is to shown that high BRASS score at admission of patient without neurologic disorder sedated is predictive of 28-day mortality.
详细描述
Sedation is used for 30 to 70 % of all intensive care unit (ICU) patients. Deep sedation can be used for lot of disease like acute respiratory distress syndrome, septic shock.
Deep sedation was defined by RASS (Richmond Assessment Sedation Scale) below -3.
Deep sedation can be associated with increased mortality, length stay, duration of mechanical ventilation, acute brain dysfunction.
The french exploration neurologic group in ICU developed a score used Brainstem response patterns in patient deeply sedated by midazolam and showed that a high BRASS score is associated with high mortality at day 28.
The investigators think that BRASS score isn't associated with the medication used for sedation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient more than 18 years Hospitalized in ICU Without neurologic disorder and/or neurologic pattern Under sedation and mechanical ventilation
排除标准
- •Patients with legal protection No affiliation with the French Health Care system Ongoing pregnancy Inability to obtain consent Not to resuscitate decision Neurologic disorder
结局指标
主要结局
mortality within 28 days after ICU admission
时间窗: 28 days
percentage of patients who died within 28 days after admission
次要结局
- ICU Stay(6 months)
- Delirium(6 months)
- mortality within 90 days after ICU admission(90 days)
- duration on mechanical ventilation(6 months)