Effect of oral clonidine and oral tizanidine on the induction dose of propofol and intubation response in general anesthesia-comparative study.

direct laryngoscopy and intubation may results in increase in blood pressure and heart rate which inturn leads to myocardial ischemia,cerebral hemorrhage and cardiac arrest in hemodynamicaly instable and susceptible patients.minimizing persistent and severe alterations in heart rate and blood pressure is critical.usual recommendations suggest maintaining heart rate and blood pressure at 20% of the basal value.alpha 2 receptor agonists decrease the catecholamine release thus can diminish the hyper dynamic status which renders the patients prone to ischemia.Hemodynamic stabilization,during and after the operations is most important mechanism by which the aplha2 receptor agonists reduce perioperative ischemia.thus we compared the drugs clonidine and tizanidine on the anesthetic requirements and the recpvery from general anesthesia.