Procedures of Locoregional Analgesia and Quality of Life in Palliative Care
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 38
- 试验地点
- 7
- 主要终点
- Change in patients global quality of life
研究概览
简要总结
Number of patients in mobile palliative care units have pain of both nociceptive and neuropathic origin. In certain cases, procedures of locoregional analgesia can be helpful.
The Purpose of this study is to evaluate the impact of techniques of locoregional analgesia in a palliative population
详细描述
Cancer pain is a serious problem in the palliative population. In particular, pain due to compression or invasion of nerve tissue by metastasis is frequent and often unresponsive to oral drug therapy and even to epidural administration of opioids. In such refractory pain in a palliative setting, one modality that could be helpful is the use of technics of locoregional analgesia. Currently, they are routinely used for the management of acute postoperative pain and become to be more widely used for cancer surgery. For example, intrapleural intercostal nerve blocks after major lung resection or preincisional paravertebral blocks after breast surgery have been shown to improve pain control. However, locoregional analgesia is only occasionally used in chronic cancer pain.
The procedures used are epidural analgesia, rachianesthesia, or continuous nerve blocks. L-bupivacaine will be used. The procedure will be performed only if the injection test is positive.
The patients will be evaluated before and after the procedure, the patient being his/her own control. Evaluations will take place immediately before the procedure, then at 48 hours, 1 week and 1 month after the procedure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient ≥ 18 years-old, male or female, whatever his/her ethnic group
- •Patient with untreatable cancer
- •Patient hospitalized in a palliative care unit, with a life expectancy ≥ 1 week
- •Pain unresponsive to conventional treatments
- •Effectiveness of the injection test
- •Signed informed consent
排除标准
- •Patients > 18 years-old
- •Patients with pain other than cancer pain
- •Patient's refusal
- •Coagulation disorders
- •Local infection
- •Known hypersensitivity to local analgesics
- •Inefficacy of the injection test.
- •Contraindication for analgesics
结局指标
主要结局
Change in patients global quality of life
时间窗: 1 week after first injection
To evaluate the change in patients global quality of life, assessed by the item 15 of the validated quality of life scale EORTC QLQ-C15 PAL. Evaluations will take place before the procedure of locoregional analgesia and 1 week after.
次要结局
- change in patient's global quality of life(2 days and 1 week after procedure)